cancersMDPIArticleDiagnostic and Therapeutic Algorithm for Appendiceal Tumorsand Pseudomyxoma Peritonei:A Consensus of the PeritonealMalignancies Oncoteam of the Italian Society of SurgicalOncology (SICO)Marco Vaira1,Manuela Robella1,Marcello Guaglio2,Paola Berchialla 3,Antonio Sommariva 4,Mario Valle 5,Enrico Maria Pasqual 6,Franco Roviello 7,Massimo Framarini 8,Giammaria Fiorentini 9Paolo Sammartino 10,Alba llari Civit1,Andrea Di Giorgio 11,Luca Ansaloni 12 and Marcello Deraco2Unit of Surgical Oncology,Candiolo Cancer Institute,FPO-IRCCS,10060 Candiolo,Italy2Peritoneal Sur face Malignancies Unit,Fondazione Istituto Nazionale Tumori IRCCS Milano,20133 Milano,ItalyDepartment of Clinical and Biological Sciences,Centre for Biostatistics,Epidemiology and PublicHealth (C-BEPH),University of Torino,10124 Torino,ItalyAdvanced SurgicalOncology Unit,Surgical Oncology of the Esophagus and Digestive Tract,Veneto Instituteof Oncology IOVIRCCS,t,35100 Padova,ItalyPeritoneal Tumours Unit,IRCCS Regina Elena NationalCancer Institute,00144 Rome,Italy6AOUD Center Advanced Surgical Oncology,DAME University of Udine,33100 Udine,Italy7Unit of GeneralSurgery and SurgicalOncology,Department of Medicine,Surgery,and Neurosciences,University of Siena,53100 Siena,ItalySurgery and Advanced Oncological Therapy Unit,Ospedale "GB.Morgagni-LPierantoni"-AUSL Forli,sahe47122 Forli,Italy9Italian Network of International Clinical Hyperthermia Society Coordinator,48121 Ravenna,ItalyCitation:Vaira,M;Robella,M;10CRS and HIPEC Unit,Pietro Valdoni,Umberto I Policlinico di Roma,00161 Roma,ItalyGuag lio,M;Berchialla,P;Surgical Unit of Peritoneum and Retroperitoneum,Fondazione Policlinico Universitario A.Gemelli-IRCCS,Sommariva,A.;Valle,M;Pasqual00168 Rome,Italy12E.M.;Roviello,F;Framarini,M.;Unit of GeneralSurgery,San Matteo Hospital,27100 Pavia,ItalyCorrespondence:authors:marco.vaira@ircc.it(M.V.);manuela robella@ircc.it(M.R.)Fiorentini,G;et al.Diagnostic andTherapeutic Algorithm forAppendiceal Tumors andSimple Summary:Pseudomyxoma peritonei(PMP)is an uncommon pathology,and its rarity causesPseudomyxoma Peritonei:Aa lack of scientific evidence,precluding the design of a prospective trial.A diagnostic and therapeuticConsersus of the Peritonealalgorithm(DTA)is necessary in order to standardize disease treatment while balancing optimalMalignancies Oncoteam of the Italianpatient management and the correct use of resources.The Consensus of the Italian Society of SurgicalSociety of Surgical Oncology (SICO)Oncology(SICO)Oncoteam aims at defining a diagnostic and therapeutic pathway for PMP andCancers 2023,15,728.https://appendiceal primary tumors applicable in Italian healthcare.doiong /10.3390/cancers15(B0728Academic Editor Guoxiang CaiAbstract:Aim:Pseudomyxoma peritonei(PMP)is an uncommon pathology,and its rarity causes alack of scientific evidence,precluding the design of a prospective trial.A diagnostic and therapeuticReceived:4 November 2022algorithm(DTA)is necessary in order to standardiz