價Check for updatesReceived:7 December 2022 Revised:20 January 2023 Accepted:21January 2023D0L10.1002/hpr2.12323NEUROPSYCHOPHARMACOLOGYREPORTSORIGINAL ARTICLEWILEYManagement of unspecified anxiety disorder:ExpertconsensusHitoshi Sakurai Ken Inada2 Yumi Aoki3 Masahiro Takeshima4 Kenya le5.6Morito Kise?Eriko Yoshida3 Takashi Tsuboi Hisashi Yamada?Hikaru Hori10Yasushi Inada1 Eiji Shimizu1213 Kazuo Mishima Koichiro WatanabeYoshikazu Takaesu114Department of Neuropsychiatry.Kyorin University Faculty of Medicine.Tokyo.JapanDepartment of Psychiatry.School of Medicine,Kitasato University.Kanagawa,Japan3Psychiatric and Mental Health Nursing.St.Luke's International University,Tokyo,JapanDepartment of Neuropsychiatry,Akita University Graduate School of Medicine,Akita,Japan5Division of General Internal Medicine,Department of Internal Medicine,St.Marianna University School of Medicine,Kanagawa,JapanDivision of General Internal Medicine.Department of Internal Medicine,Kawasaki Municipal Tama Hospital,Kanagawa,JapanCentre for Family Medicine Development.Japanese Health and Welfare Co-operative Federation.Tokyo.JapanDepartment of General Intemal Medicine,Kawasaki Kyodo Hospital,Kawasaki Health CooperativeAssociation,Kanagawa,JapanDepartment of Neuropsychiatry.Hyogo Medicial University.Hyogo,JapanDepartment of Psychiatry,Faculty of Medicine,Fukuoka University.Fukuoka.Japan1Medical corporation YUJIN-KAI Inada Clinic,Osaka,Japan12Research Center for Child Mental Development,Chiba University.Chiba,Japan1Department of Cognitive Behavioral Physiology.Graduate School of Medicine,Chiba University.Chiba,Japan14Department of Neuropsychiatry.Graduate School of Medicine.University of the Ryukyus,Okinawa.JapanCorrespondenceYoshikazu Takaesu,Department ofAbstractNeuropsychiatry,Graduate School ofMedicine,University of the Ryukyus,207Aims:Treatment guidelines with respect to unspecified anxiety disorder have notUehara,Nishihara,Okinawa 903-0215,been published.The aim of this study was to develop a consensus among field expertsJapan.on the management of unspecified anxiety disorder.Email:takaesuy@med.u-ryukyu.ac.jpMethods:Experts were asked to evaluate treatment choices based on eight clinicalFunding informationquestions concerning unspecified anxiety disorder using a nine-point Likert scaleMinistry of Health,Labor and Welfare ofJapan,Grant/Award Number:21GC1016(1 "disagree"to 9="agree").According to the responses from 119 experts,thechoices were categorized into first-,second-,and third-line recommendations.Results:Benzodiazepine anxiolytic use was not categorized as a first-line recommen-dation for the primary treatment of unspecified anxiety disorder,whereas multiplenonpharmacological treatment strategies,including coping strategies(7.9+1.4),psy-choeducation for anxiety(7.9±1.4)，lifestyle changes(7.8±1.5)，and relaxation tech-niques(7.4+1.8),were categorized as first-line recommendations.Various treatmentstrategies were categorized as first-line recommendations when a benzodiaz
