Current Medical Science43(1:1-12,2023D0 I https:∥doi.org/10.1007s11596-022-2693-2Expert Consensus on the Diagnosis and Treatment of Anticancer Drug-Induced Interstitial Lung Disease"Anticancer Drug-induced Interstitial Lung Disease Diagnosis and Treatment Group,ChinaInterstitial Lung Diseases Panel,Chinese Medical Association-Chinese Thoracic Society and Chinese Medical DoctorAssociation-Chinese Association of Chest Physicians,ChinaThe Author(s)2023Abstract]Drug-induced interstitial lung disease (DILD)is the most common pulmonary adverseevent of anticancer drugs.In recent years,the incidence of anticancer DILD has gradually increasedwith the rapid development of novel anticancer agents.Due to the diverse clinical manifestationsand the lack of specific diagnostic criteria,DILD is difficult to diagnose and may even becomefatal if not treated properly.Herein,a multidisciplinary group of experts from oncology,respiratory,imaging,pharmacology,pathology,and radiology departments in China has reachedthe "expert consensus on the diagnosis and treatment of anticancer DILD"after several rounds ofa comprehensive investigation.This consensus aims to improve the awareness of clinicians andprovide recommendations for the early screening,diagnosis,and treatment of anticancer DILDThis consensus also emphasizes the importance of multidisciplinary collaboration while managingDILD.Key words:drug-induced interstitial lung disease;anticancer drug;diagnosis;treatmentDrug-induced lung injury is an injury inkinase inhibitor(TKI),mammalian target of rapamycinthe respiratory system,i.e.,the airways,lung(mTOR),antibody-drug conjugates (ADCs),andparenchyma,pulmonary vessels,and pleura,thatimmune checkpoint inhibitors (ICIs),the incidence ofresults from drug administration.The most commonanticancer DILD has gradually increasedu.However,drug-induced lung injury is drug-induced interstitialcompared with drug-induced liver and kidney injuries,lung disease (DILD).21.In recent years,with thedrug-induced lung injury has not attracted significantemergence of new anticancer agents such as tyrosineattention in clinical practicelMisdiagnoses and missed diagnoses of DILD arenot rare due to the diverse clinical manifestations andCorresponding authors,Fei MA,E-mail:drmafei@126.the lack of specific diagnostic methodsPl.If not treatedcom,Department of Medical Oncology,National Cancerproperly,it may interrupt or discontinue anticancerCenter,National Clinical Research Center for Cancer,treatment or even become life-threatening in severeCancer Hospital,Chinese Academy of Medical Sciences andcases.As a result,it is very important for clinicians toPeking Union Medical College,Beijing 10021,China;Hua-promptly recognize,identify,and manage anticancerping DAI,E-mail:daihuaping @ccmu.edu.cn,Departmentof Pulmonary and Critical Care Medicine,China-Japandrug-induced lung injury.Herein,we discussed theFriendship Hospital,National Center for Respiratorydiagnosis and treatment of DILD with experts fromMe
