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Neurol TherCheck forhttps::/ldoi.org/10.1007/s40120-023-00439-yupdatesREVIEWAssisted Reproductive Techniques in MultipleSclerosis:Recommendations from an Expert PanelCelia Oreja-Guevara Aintzane Rabanal.Corazon Hernandez Rodriguez.Yolanda Aladro Benito·Mar Mendibe Bilbao·Ines Gonzalez-Suarez·Jose Luis Gomez-PalomaresReceived:November 23,2022/Accepted:January 12,2023©The Author(s2023ABSTRACTMethods:A group of seven MS experts (4 neu-rologists and 3 gynaecologists)came togetherIntroduction:Multiple sclerosis (MS)is mainlyfor three discussion sessions to achievediagnosed in women of reproductive age.consensus.However,there is a paucity of guidelines jointlyResults:The recommendations reported hereprepared by neurologists and gynaecologists onfocus on the importance of early preconceptionmanaging women with MS and the desire forcounselling,the management of disease-modify-motherhood.Therefore,in this review we pro-ing therapies before and during ART procedures,pose recommendations for such cases,with animportant considerations for women with MSparticular focus on those requiring assistedregarding ART (intrauterine insemination,reproductive techniques (ART).in vitro fertilisation and oocyte cryopreservation)and the paramount relevance of multidisciplinaryunits to manage these patients.Celia Oreja-Guevara and Jose Luis Gomez-PalomaresConclusions:Early preconceptionconsulta-contributed equally to this work.tions are essential to individualising pregnancyC.Oreja-Guevara(☒)Department of Neurology,Health Research InstituteY.A.Benitoof the Hospital Clinico San Carlos (IdISSC),HospitalDepartment of Neurology,Research Institute,Clinico San Carlos,Madrid,SpainHospital Universitario de Getafe,Madrid,Spaine-mail:orejacbn@gmail.comM.M.BilbaoC.Oreja-GuevaraNeuroscience Department,Biocruces HealthDepartamento de Medicina,Facultad de Medicina,Research Institute,Cruces University Hospital,Universidad Complutense de Madrid(UCM),University of the Basque Country,Bilbao,SpainMadrid,SpainI.Gonzalez-SuarezA.RabanalDepartment of Neurology,Hospital AlvaroHuman Reproduction Unit,Obstetrics andCunqueiro,Vigo,SpainGynaecology Department,Biocruces HealthI.L.Gomez-PalomaresResearch Institute,Cruces University Hospital,Wilson Fertiliy-Balearic Center for In VitroUniversity of the Basque Country,Bilbao,SpainFertilization CEFIVBA-Wilson Fertility,Mallorca,C.H.RodriguezSpainAssisted Reproduction Institute,Fundacion JimenezDiaz,Madrid,Spain△AdisPublished online:07 February 2023
