角Check for updatesReceived:20 May 2022 Accepted:9 September 2022D0l:10.1111/dd9.14930DDGGUIDELINES2k Guideline-Merkel cell carcinoma(MCC,neuroendocrinecarcinoma of the skin)-Update 2022Jurgen C.Becker1|Ambros J.Beer2 Viola K.DeTemple3 Thomas Eigentler4Michael Flaig5 Thilo Gambichlers Stephan Grabbe7 I Ulrike HollersBernhard Klumpp Stephan Lang10 Claudia Pfohler11 Christian Posch12Vikas Prasad13 Peter Schlattmann14 Sylke Schneider-Burrus15 Jan Ter-Nedden16Patrick Terheyden17 I Kai Thoms18 Dirk Vordermark19 Selma Ugurel20Translational Skin Cancer Research(TSCR),Deutsches Konsortium fur translationale Krebsforschung (DKTK)Partnerstandort Essen,Department of Dermatology,UniversityHospital Essen,German Cancer Research Center (DKFZ,Heidelberg2Department of Nudear Medicine,University HospitalUlm3Department of Dermatology,Venereology,Allergology and Phlebology,Johannes Wesling Klinikum,MindenDepartment of Dermatology,Venereology and Allergology,University Hospital Berlin5Department and Oinic for Dermatology and Allergology,LMU Klinikum MunichDepartment of Dermatology,Venereology and Allergology,Ruhr University Bochum7Department of Dermatology,University Hospital MainzRadiation Therapy,MVZCharite Vivantes,BerlinRadiology,Rems-Murr-Kliniken WinnendenDepartmentof Ear,Nose and Throat Medicine,University HospitalEssenDepartment of Dermatology,University HospitalSaarland Homburg/SaarDepartment of Dermatology Campus Biederstein,Technical University MunichDepartment of Nudear Medicine,University Hospital lmMedical Statistics and Epidemiology,University HospitalJenaDepartmentof Dermatosurgery,Havelklinik,BerlinProfessional Association of German Dermatologists,HamburgDepartment of Dermatology,Venereologyand Allergology,University HospitalSchleswig-Holstein,CampusLubeckDepartmentof Dermatology,Venereologyand Allergology,University HospitalGottingen,GttingenUniversity HospitalandClnicfor Radiation Therapy,HalleDepartment of Dermatology,Venereologyand Allergology,University Hospital EssenCorrespondenceProf.Dr.med.Dr.rer.nat.Jurgen C.BeckecSummaryTranslational Skin Cancer Research (TSCR).Merkel cell carcinoma(MCC,ICD-O M8247/3)is a rare,malignant,primary skinDepartment of Dermatology and West GermanTumor Center,University Hospital Essentumor with epithelial and neuroendocrine differentiation.The tumor cells shareUniversitatsstraBe 1,45141 Essen.many morphologic,immunohistochemical,and ultrastructural features with cuta-Email:j.becker@dkfz-heidelberg.deneous Merkel cells.Nevertheless,the cell of origin of MCC is unclear.MCC appearsThis guideline has been updated from the 52k guideline published in 2018.Sections that did not require updating have in some cases been adopted from the former guidelinewithout change.Information on methods,conflicts of interest,and validity of the guideline can be found in the AWMF guideline report.This is an open access artide under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License,which permits use and distributi
