42肿瘤代谢与营养电子杂志2023年2月9日第10卷第1期Electron J M4 ab Nutr Cancer,Feb.9,2023,Vd.10,No.1·专家论坛·D0l:10.16689/i.cnki.m11-9349/r.2023.01.007变态反应肿瘤学立场文件解读2陈力嘉，'王洪田，2王学艳（首都医科大学附属北京世纪坛医院变态反应科，北京100038,2首都医科大学附属北京世纪坛医院变态反应中心，北京100038)摘要：变态反应肿瘤学(AllergoOncology)是由变态反应学与肿瘤学合成的名词。变态反应与肿瘤的关系早在数十年前就被关注和研究。1960年代首次发现了变态反应与肿瘤发病间存在负相关关系。此后，该领域中有关基础、转化和临床的相关研究层出不穷。2014年由Erika Jensen-Jarolim教授牵头在欧洲变态反应与临床免疫学会(EAAC)成立了跨学科、跨领域的变态反应肿瘤学工作组，旨在建立常态化的变态反应肿瘤学成果交流平台，促进该学科深入持续发展。工作组关注变态反应和肿瘤学的交叉点，致力于免疫监视、免疫调节和gE介导的肿瘤免疫治疗等研究，发布了5个变态反应肿瘤学的立场文件，促进了变态反应的核心理论向抗肿瘤临床实用技术转化，希望进一步提高肿瘤临床疗效。本文结合变态反应与肿瘤学领域相关文献，从变态反应与肿瘤间的负相关性、变态反应重要分子gE的抗肿瘤效应、免疫细胞和分子以及微生物群分别在变态反应和肿瘤中的作用和变态反应肿瘤学的转化应用等方面，对变态反应肿瘤学立场文件进行归纳、比较、总结及要点解读。关键词：变态反应肿瘤学：变态反应：肿瘤：免疫学：微生物群AllergoOncology position papers interpretation1.2Chen Lijia,Wang Hongtian,2Wang XueyanAllergy Department,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038.China:Allergy Center,Beijing ShijitanHospital,Capital Medical University,Beijing 100038,ChinaAbstract:AllergoOncology is a combination of allergy and oncology.The relationship between allergy and tumor has beendiscussed and studied decades ago.In the 1960s,a negative correlation between allergy and tumor morbidity was firstdiscovered.Since then,there has been an endless stream of related researches on basic,translational and clinical medicine in thisfield.In 2014,a Task Force on AllergoOncology was established at the European Association of Allergy and Clinical Immunology(EAACI)led by Professor Erika Jlensen-Jarolim,aiming to establish a routine platform for allergy oncology achievements.Focusing onthe intersection of allergy and oncology,the working group is dedicated to research on immune surveillance,immune regulation,andIgE-mediated tumor immune responses,and has issued 5 position papers on AllergoOncology.It has promoted the transformation of thecore theory of allergy into clinical practical cancer treatment,and is expected to further improve the therapeutic efficacy efficacy oftumors.This article interprets the position papers of AllergoOncology from the negative correlation between allergy and tumor,effectorscells and molecules and microbiota in allergy and cancer,and translational strategies in AllergoOncology based on novel insights intothe field of AllergoOncology.Key words:AllergoOncology:Allergy:Tumor:Immunology:Microbiome肿瘤可以影响免疫系统，而免疫系统决定肿瘤生、发展产生潜在作用。当机体免疫力过强或免疫的免疫监视和临床过程。流行病学研究表明变态耐受受损则可能导致变态反应性疾病，而免疫力低反应性疾病和部分恶性肿瘤之间存在负相关[2】。下或免疫耐受过度则可能导致肿瘤发生。通常，变有研究证实，机体的免疫能力对肿瘤的免疫监视和态反应和肿瘤代表了两个相反的方向，虽然免疫耐疾病进展产生关键性影响，而肿瘤对免疫反应也可受对变态反应来说是最理想的，但对肿瘤来说却是以产生相应的反馈作用)。过敏或特应性体质导有害的。因此，欧洲变态反应与临床免疫学会(Eo致机体向T2免疫反应产生倾斜，这也对肿瘤的发pean Academy of Allergy and Clinical Immunology,基金项目：北京市教育委员会科研计划项目(K☑202110025030)EAACI)为顺应科学发展的需要成立了变态反应肿首都医科大学附属北京世纪坛医院科研课题(2021-g18)瘤学工作组(a task force on AllergoOncolog罗y),该工通信作者：王洪田，电子邮箱：wht301@263.n4作组将对Th2免疫反应和恶性肿瘤感兴趣的基础(C)1994-2023 China Academic Journal Electronic Publishing House.All rights reserved.http://www.cnki.net
