·170·生殖医学杂志2023年2月第32卷第2期D0I:10.3969/5issn1004-38452023.02002精子DNA碎片检测的临床专家共识倪吴花，Ashok Agarwal,孙莹璞，孙海翔，邓成艳，刘平，周灿权，冯云，郝桂教，户文红，全松，沈浣，师婿子，滕晓明，王晓红，王秀霞，伍琼芳，曾勇，张松英，钟彩，黄学锋*，黄国宁(中华医学会生殖医学分会第五届委员会》【摘要】精子DNA碎片(sperm DNA fragmentation,SDF)在男性不有症中发生率较高，SDF常伴发少，弱精子症，也可发生于常规精液指标正常的不育症患者，其发生机制包括精子成熟障碍，湖亡异常和氧化应激过高等，由于很多文献报道其与自然妊娠和辅助生殖技术结局存在负相关，SDF检测已在男性不育症和辅助生殖技术中得到越来越广泛的应用，本专家共识复习和评估了SDF相关文献，对SDF的危险因素，检测方法，临床意义和处理等提出2项良好实践要点和9项推荐建议，本共识大部分推荐建议的证据和级别属于低或中等，表明仍需要进一步的研究证实临床应用SD℉检测的价值。【关键词】男性不有：精子DNA碎片：辅助生殖技术【中图分类号】R3211:R698+.2【文献标识码】AClinical expert consensus on sperm DNA fragmentation detectionNI Wu-hua,Ashok Agarwal,SUN Ying-pu,SUN Hai-xiang,DENG Cheng-yan,LIU Ping,ZHOU Can-quan,FENG Yun,HAO Gui-min,LU Wen-hong,QUAN Song,SHEN Huan,SHIJuan-zi,TENG Xiao-ming,WANG Xiao-hong,WANG Xiu-xia,WU Qiong-fang,ZENG Yong,ZHANG Song-ying,ZHONG Ying,HUANG Xue-feng*,HUANG Guo-ning*The Fifth Committee of Chinese Society of Reproductive Medicine,Chinese Medical Association[Abstract]The incidence of sperm DNA fragmentation(SDF)is higher in male infertile patient.SDFis often associated with oligozoospermia and asthenospermia,and can also occur in infertile patients withnormal conventional semen parameters.The mechanisms include abnormal spermatozoa maturationprocess,abnormal apoptosis,and high oxidative stress.SDF detection has been widely used in maleinfertility and assisted reproductive technology(ART)due to the negative correlation between SDF and theoutcome of natural pregnancy and ART reported in many literatures.This expert consensus reviewed andevaluated SDF related literature,and proposed 2 good practice points and 9 recommendations on riskfactors,detection methods,clinical significance and treatment of SDF.The evidence and level of the mostrecommendations in this consensus are low or medium,indicating that further research is still needed toconfirm the value of clinical application of SDF detection.[Key words]Male infertility;Sperm DNA fragmentation;Assisted reproductive technology(J Reprod Med2023,32(02):170-180)背性不育症患者。SDF的发生机制复杂。很多文献报景道SDF升高与自然妊娠和辅助生殖技术结局存在负常规精液指标是目前评估男性生育力的主要手段，但研究已发现其预测男性生育力的价值有限)。【收稿日期】2022-11-05精子DNA碎片(sperm DNA fragmentation,SDF)是【作者简介】倪吴花，温州医科大学附属第一医院生殖医学中心一项新的反映精子功能的检测指标。SDF增高常伴(*通讯作者：黄学锋xuefhuang@wmu edu c:黄国宁gnhuan217@发少，弱精子症，也可发生在精液常规指标正常的男sina com)
