本刊特稿一密抗呼吸道RNA病毒的小分子药物应用专家意见Expert Opinion on Application of Small Molecule Drugs Against RespiratoryRNA Viruses沈姗12，聂瑞芳1，侯宁12“[摘要]呼吸道感染性疾病是临床最常见的流行性疾病之一，据统计，80%以董亮3，张锦涛3，唐琳，张薇1，上的总性上呼吸道感染是由病毒感染引起。近年来，新型冠状病毒感染大流行、流感病毒感染高发使呼吸道核糖核酸(RNA)病毒感染成为社会关注的焦点。杨效双14，许珂5，季翔3，张键宁3，小分子抗病毒药为目前备受关注的抗呼吸道病毒感染的治疗方案。为进一步促王光海3，鲁德开3，王春亭1进抗呼吸道RNA病毒的小分子药物的合理应用，有效提高呼吸道RNA病湖药物治疗水平，山东省药学会循证药学专委会与山东省新冠病毒感染重症救治[作者简介]沈姗。女，主管药师，专业方专家组联合，结合国内外最新研究成果，制订了《抗呼吸道RNA病毒的小分向：循证药学与抗感染药物研究。mail:子药物应用专家意见》。13723231135@163.00m。[通讯作者】侯宁，女，主任药师，硕士研[关键词]呼吸道感染；RNA病毒；小分子抗病毒药物；专家意见；蛋白酶抑制剂究生导师。专到业方向：药管理与循正药学。[中图分类号]R978.7[文献标志码]A[文编号]2096-3327(2023)05-001-14E-mail:hou ning@sina.comeD0I10.3969/j.issn.2096-3327.2023.05.001董亮，男。主任医师。教授。博士研究生导师，专业方间：呼吸道感染性疾病及慢[Abstraet Respiratory tract infection is one of the most common clinical epidemic diseases According to性气道疾病的基础及转化医学。-ail:statistics more than 80%of acute upper respiratory tract infection is caused by virus infection.Recently.dl5506@126.com.respiratory ribonucle ic acid (RNA)virus infection has become the focus of attention due to the COVID-19pandemic and high incidence of influenza virs infection.Small molecular antiviral drugs are the currentlyrecommended against respiratory viruses therapy.In order to further promote the rational use of small1山东第一医科大学附属省立医院，济南molecule drugs against respiratory RNA viruses and effectively improve the therapeutic efficacy of drugsagainst respiratory RNA viruses,the Expen Opinions on the Application of Small Molecule Drugs Against250021:2山东省药学会循证药学专业委员会，Respiratory RNA Viruses is formulated by the Specialized Committee of Evidence-Based Pharmacy of济南250021；3山东第一医科大学第一附属Shandong Pharmaceutical Association and the Expert Group on the Treatment of Severe COVID-19 Infection医院，济南250021：4山东弟一医科大学（山in Shandong Province based on the latest research results at home and abroad东医学科学院)研究生部，济南250021：5[Key words|respiratory tract infection RNA virus small molecular antiviral drugs;expert opinions protease山东大学生殖医学研究中心，济南250021inhibitorSHEN Shan,NIE Rui-fang',HOU Ning2DONG Liang.ZHANG Jin-tao.TANG Lin'ZHANG Wei,YANG Shuang-shuang'4,XUKe,JI Xiang',ZHANG Jian-ning,WANG1背景Guang-hai,LU De-gan,WANGChun-ting'随着近几年新型冠状病毒感染(C0VID-19)的大流行，呼吸道病毒已成为全球关注的焦点。引起呼吸道感染的病毒包括脱氧核糖核酸1 Shandong Provincial Hospital Affiliated toShandong First Medical University,Jinan(deoxyribonucleic acid,DNA)病毒和核糖核酸(ribonucleic acid,250021,China;2 Evidenoe-Based PhammacyRNA)病毒I),其中RNA病毒包括冠状病毒(coronavirus,CoVSpecialized Committee of ShandongPhammeceufical Association,Jinan 250021,Chine;流感病毒(influenza virus,IFV,、副流感病毒(parainfluenza virus,3FrstAffialed Hospitalof Shandong First MedicalUniversity,Jinan 250021,Chna;4 GraduatePIV,呼吸道合胞病毒(respiratory syncytial virus,RSV)、人偏肺病毒Department,Shandong Frst Medical University(human metapneumovirus,hMPV)以及鼻病毒(human rhinovirus,Shandong Academy df Medical SciencesJinan 250021,China;5 Reproductive MedicineHRV)等。与DNA病毒相比，RNA病毒更容易发生碱基的增添、替换Research Center of Shandong Universty,Jinan和丢失，使得RNA病毒更容易发生变异。更为关键的是，RNA病毒可以250021,Cine2023年第05期1第
