直Check for updatesAMERICAN THORACIC SOCIETYDOCUMENTSCauses,Consequences,and Treatments of Sleep and CircadianDisruption in the ICUAn Official American Thoracic Society Research StatementMelissa P.Knauert,Najib T.Ayas,Karen J.Bosma,Xavier Drouot,Mojdeh S.Heavner,Robert L.Owens,Paula L.Watson,M.Elizabeth Wilcox,Brian J.Anderson,Makayla L.Cordoza,John W.Devlin,Rosalind Elliott,Brian K.Gehlbach,Timothy D.Girard,Biren B.Kamdar,Amy S.Korwin,Elizabeth R.Lusczek,Sairam Parthasarathy,Claudia Spies,Jag Sunderam,Irene Telias,Gerald L.Weinhouse,and Phyllis C.Zee;on behalf of the American Thoracic Society Assembly on Sleep and Respiratory NeurobiologyTHIS OFFICIAL RESEARCH STATEMENT OF THE AMERICAN THORACIC SOCIETY WAS APPROVED DECEMBER 2022AbstractResults:We identified the following research priorities:establish an ICU SCD definition,further develop rigorous andBackground:Sleep and circadian disruption(SCD)is commonfeasible ICU SCD measures,test associations between ICU SCDand severe in the ICU.On the basis of rigorous evidence in non-domains and outcomes,promote the inclusion of mechanisticICU populations and emerging evidence in ICU populations,and patient-centered outcomes within large clinical studies,SCD is likely to have a profound negative impact on patientleverage implementation science strategies to maximizeoutcomes.Thus,it is urgent that we establish research prioritiesintervention fidelity and sustainability,and collaborate amongto advance understanding of ICU SCD.investigators to harmonize methods and promote multisiteinvestigationMethods:We convened a multidisciplinary group with relevantexpertise to participate in an American Thoracic Society Workshop.Conclusions:ICU SCD is a complex and compelling potentialWorkshop objectives included identifying ICU SCD subtopics oftarget for improving ICU outcomes.Given the influence on allinterest,key knowledge gaps,and research priorities.Membersother research priorities,further development of rigorous,attended remote sessions from March to November 2021.Recordedfeasible ICU SCD measurement is a key next step in advancingpresentations were prepared and viewed by members beforethe field.Workshop sessions.Workshop discussion focused on key gaps andrelated research priorities The priorities listed herein were selectedKeywords:sleep deficiency;circadian rhythm;delirium;criticalon the basis of rank as established by a series of anonymous surveys.illness;research prionty8You may print one copy of this document at no charge.However,if you require more than one copy,you must place a reprint order.Domesticreprint orders:amy.schriver@sheridan.com;intemational reprint orders:louisa.mott@springer.com.0RCID1Ds:0000-0002.7341-850XM.P.K.):0000-0003-0423-7286(K.J.B.):0000-0002-3940-4825X.D.):0000-0003-3007-7685M.S.H.):0000-0002-.6515-6204(R.L.0.:0000-0002.9058-6118M.E.W.):0000-00015727.2718(M.L.C.):0000-0002-9239-7126(R.E.:0000-0003-3160-1741(B.K.G.0000-0002-9833.4871(T.D.G.):0000-0002-9245-6229(B.B.K.):0000-0003-4680965X
