第21卷第1期临床药物治疗杂志Vol.21,No.12023年1月Clinical Medication JournalJanuary,2023·新型冠状病毒感染的药物治疗·编者按2022年12月以来，随着新型冠状病毒感染疫情防控措施的优化，我国对新型冠状病毒感染实施“乙类乙管”，感染人数短期内快速增加，医疗资源经受到严重挑战；同时《新型冠状病毒感染诊疗方案（试行第十版）》将奈玛特韦片/利托那韦片纳入新版诊疗方案中，此药由于其药物代谢动力学特点，易与多种药物发生相互作用。本刊编辑部特组织7篇相关文章，分别从不同角度阐述当前形势下的合理用药、安全用药问题，以为临床用药提供参考。奈玛特韦片利托那韦片与心血管药物相互作用实用药学建议《奈玛特韦片/利托那韦片与心血管药物相互作用实用药学建议》编写组【摘要】新型冠状病毒感染治疗药物奈玛特韦片/利托那韦片（简称奈/利片）在我国应用日益广泛，但其药物相互作用复杂。尽管说明书、国内外指南提供了奈/利片与心血管药物合用处置建议，但直接用于指导我国临床实践仍有一定局限性，包括国内外药品品种不完全一致、部分推荐意见无法实施等。为此，北京药学会和首都医科大学附属北京安贞医院联合发起，组织医学和药学专家，在系统整理相关资料的基础上，充分考虑我国药品品种情况，结合临床实践经验制定《奈玛特韦片/利托那韦片与心血管药物相互作用实用药学建议》，涉及奈/利片与临床常用心血管药物间相互作用机制、相互作用结果、相互作用级别和实用药学建议，旨在为我国临床实践提供参考。【关键词】新型冠状病毒感染；奈玛特韦片/利托那韦片；心血管药物；相互作用【中图分类号】R978.7:R969.2【文献标识码】A【文章编号】1672-3384(2023)01-0001-09Doi:10.3969/j.issn.1672-3384.2023.01.001Practical pharmacological advice on the drug-drug interactions of nirmatrelvir/ritonavirtablets with cardiovascular drugsWriting group of Pructical Phamacological Advice on the Drug-Dng Interactions of Nimatrelinf Ritonavir Tablets with Cardiovascular Drugs[Abstract)Nirmatrelvir/ritonavir tablets are widespread used in China,which is a novel therapeutic drug for coronavirus in-fection.Nevertheless,it has complicated interactions with other drugs.Although the instructions and guidelines at home andabroad provide recommendations for the co-administration of nirmatrelvir/ritonavir tablets with cardiovascular drugs,there arestill limitations for guiding clinical practice in China,including the inconsistency of drug varieties at home and abroad,and the in-ability to implement some recommendations.Therefore,the Beijing Pharmaceutical Association and Beijing Anzhen Hospital.Capital Medical University organized medical and pharmacy experts to develop "practical pharmacological advice on the drug-drug interactions of nirmatrelvir/ritonavir tablets with cardiovascular drugs"based on relevant information,the situation of drugs,and the clinical practice experience in China.It contains the interaction mechanism,interaction results,and interaction levels,aswell as the practical pharmacological recommendations between nirmatrelvir/ritonavir tablets and commonly used cardiovasculardrugs in clinical practice,with the aim of providing references for clinical practice in China.[Key words]Corona Virus Disease 2019;Nirmatrelvir/Ritonavir;cardiovascular drugs;drug interaction通信作者：林阳.博士，主任药师。研究方向：药事管理，精准临床药物治疗。E-mail:linyang3623@163.com·1·
