青少年女性人乳头瘤病毒疫苗免疫策略与实践长三角地区专家共识

中华预防医学杂志2023年2月第57卷第2期Chin J Prev Med,.February2023.Val.57,No.2·135·标准·指南·共识·青少年女性人乳头瘤病毒疫苗免疫策略与实践长三角地区专家共识中国疫苗行业协会免疫规划规范化管理与实践分会道信作者：孙晓冬，上海市疾病预防控制中心，上海200336，Email:sunxiaodong@scdc.sh.cn【摘要】高危型别的人乳头瘤病毒(HPV)持续感染是发生子宫颈癌的主要原因。为实现消除子宫颈癌的目标，WH0提出“90-70-90”的战略目标，其中之一即是“90%的女孩在15岁之前完成HPV疫苗接种”。基于HPV感染的流行病学特征和HPV疫苗的特性，优先保障青少年女性接种HPV疫苗至关重要。中国疫苗行业协会免疫规划规范化管理与实践分会组织专家组制定了《青少年女性人乳头瘤病毒疫苗免疫策略与实践长三角地区专家共识》。本共识依据国内外关于青少年接种HPV疫苗的最新研究进展，结合我国长三角地区的人群特征，HPV感染和子宫颈癌的流行特点，介绍了HPV感染及相关疾病负担、青少年女性接种HPV疫苗的安全性和有效性、影响青少年女性接种HPV疫苗健康获益的因素、现有青少年女性HPV疫苗接种策略、长三角地区青少年女性接种HPV疫苗的专家建议及常见问题和注意事项等内容，旨在指导长三角地区青少年女性HPV疫苗接种，并为其他地区提供借鉴。【关键词】青少年；人乳头瘤病毒；疫苗；长三角地区；专家共识Expert consensus on the immunization strategy and practice of human papillomavirusvaccine for female adolescents in the Yangtze River Delta regionAffiliated Association for Standardized Management and Practice of Immunization Program,ChinaAssociation for VaccinesCorresponding author:Sun Xiaodong,Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China,Email:sunxiaodong@scdc.sh.cnAbstract Persistent infection of high-risk human papillomavirus (HPV)is the leadingcause of cervical cancer.In order to achieve the goal of cervical cancer elimination,the World HealthOrganization (WHO)proposed the "90-70-90"goal,one of which is"90%of girls fully vaccinatedwith HPV vaccine by age 15 years".Based on the epidemiological characteristics of HPV infectionand the characteristics of HPV vaccine,it is important to give priority to female adolescents to bevaccinated with HPV vaccine.CAV Affiliated Association for Standardized Management and Practiceof Immunization Program organized an expert group to develop an expert consensus on theimmunization strategy and practice of human papillomavirus vaccine for female adolescents in theYangtze River Delta region.This consensus introduces HPV infection and related disease burden,safety,efficacy and effectiveness of HPV vaccination for female adolescents,factors affecting thehealth benefits of HPV vaccination for female adolescents,current HPV vaccination strategies forfemale adolescents,the expert advice,common problems and precautions in the Yangtze River Deltaregion.This consensus is developed to guide HPV vaccination for female adolescents in the YangtzeRiver Delta region and provide reference for other regionsD01:10.3760/cma.j.cm112150-20221110-01093收稿日期2022-11-10本文编辑张振伟引用本文：中国疫苗行业协会免疫规划规范化管理与实践分会.青少年女性人乳头瘤病毒疫苗免疫策略与实践长三角地区专家共识中华预防医学杂志，2023,57(2135-153.D0L:10.3760/©ma.i■cn112150-20221110-01093