ARTICLE IN PRESSJournal of Geriatric Oncology xxx (xxxxx)xxxContents lists available at ScienceDirectoNcorocJournal of Geriatric OncologyELSEVIERjournal homepage:www.elsevier.com/locate/jgoSystematic reviewSignificance of the comprehensive geriatric assessment in theadministration of chemotherapy to older adults with cancer:Recommendations by the Japanese Geriatric OncologyGuideline CommitteeKiichiro Ninomiya,Daisuke Inoue,Ken Sugimoto,Chie Tanaka,Keiko Murofushi,Toru Okuyama,Shigeaki Watanuki,Chiyo K.Imamura",Daisuke Sakai',Naomi Sakurai,Kiyotaka Watanabek,Kazuo Tamura,Toshiaki Saekim,Hiroshi IshiguroCenter for Comprehensive Genomic Medicine Okayama University Hospiml Okayama JapanDepartment of Obsterics and Gynecology,Untversity of,Japan.Deparmnent of Geeral Geriatric Medicine,Kmasaki Medical School Okayana,Japand Department of Gastroenterological Surgery,Nagoya University Groduae School of Medicine,Aichi JapanDivision of Rodiation Oncology,Deparment of Radiology,Tokyo Metropolitan Cancer and Ifectious Diseases Center Komagome Hospisl,Tokyo.JapaniDeparment of Psychiatry /Palliative Care Cener,Nogoya Ciy Universtty West Medical Cener,Aichi,Japn8 National Center for Global Health and Medicine,Natonal College of Nursing Tokya JapanAdvanced Cancer Translational Research Instinte,Showa University,Tokya JapanDeparment of Fronter Sdence for Cancer ad Chemotherapy,Osaka Universiy Graduate School of Medicine,Osaka apanCancer Sobtions Co.,Ld,Tokyo,JopanDivision of Medical Oncology,Department of Medicine School of Medicine,Teikyo University,Tokyo,JapanNPO Clinical Hematology/Oncology Treatment Sndy Group,Fukoka,JopanBreost Onology Service Sama Medical University Intemational Medical Cener,Satma,ARTICLE INFOABSTRACTKeywordsIntroduction:The number of older patients with cancer is expected to continue to increase owing to the agingComprehensive geriatric assessmentpopulation.Recently,the usefulness of geriatric assessment (GA)conducted by multiple staff members fromGuidelinedifferent medical backgrounds has been reported;however,a consensus on the effectiveness of GA has not yetSystematic reviewbeen achieved.Materials and Methods:We,as the Japanese Geriatric Oncology Guideline Committee for elderly patients withcancer,conducted a literature search of randomized controlled trials published before August 2021 that used GAor comprehensive GA (CGA)as an intervention for patients with cancer undergoing chemotherapy.As the keyoutcomes for answering the clinical question,we focused on survival benefit,adverse events,and quality of life(QOL).After a systematic review of these studies,the expert panel member developed recommendations ac-cording to the Grading of Recommendations Assessment,Development,and Evaluation (GRADE)system.Results For older patients with cancer,GA or CGA is suggested during or before chemotherapy (weakly rec-ommended).Chemotherapy-induced adverse events were significantly reduced by GA/CGA interventionswithout any adverse effects on survival.He
