中国全科医学htp-/heww.chinagpnet E-mail-xgqkyx@chinagpnet.cn1·指南·共识·乌司他丁用于临床常见急危重症的专家共识《乌司他丁用于临床常见急危重症的专家共识》专家组【摘要】乌司他丁具有抑制蛋白水解酶、调控炎症反应等作用，目前主要应用于急性胰腺炎，但也被应用于休克、脓毒症、重症肺炎、急性呼吸窘迫综合征、多种急性中毒、重症中暑、重度烧伤、严重创伤等其他临床常见急危重症及心博骤停患者，而且已被临床常见急危重症诊治相关的多个指南/专家共识推荐。然而，目前关于乌司他丁的适应证及其用法、用量等尚缺乏统一意见。因此，为推动乌司他丁的规范化应用，《乌司他丁用于临床常见急危重症的专家共识》专家组针对乌司他丁的作用机制、药代动力学、适应证及在常见急危重症中的应用方法等进行了归纳、总结，以期为乌司他丁在临床工作中的合理应用提供参考。【关键词】急危重症；乌司他丁；专家共识；急性胰腺炎；休克；脓毒症；重症肺炎；急性呼吸窘迫综合征：急性中毒；重症中暑；重度烧伤；严重创伤：心搏骤停【中图分类号】R605.975R926【文献标识码】AD0I:10.121145.issn.1007-9572.2023.0157【引用本文】《乌司他丁用于临床常见急危重症的专家共识》专家组.乌司他丁用于临床常见急危重症的专家共识[J].中国全科医学，2023.[Epub ahead of print].D0I:10.12114.isn.1007-9572.2023.0157.[www.china即.net]Expert consensus on the application of ulinastatin in common clinical critical illness.Expert group of expert consensus on theapplication of ulinastatin in common clinical critical illness [J].Chinese General Practice,2023.Epub ahead of print ]Expert Consensus on the Application of Ulinastatin in Common Clinical Critical Illness Expert group of expert consensuson the application ofulinastatin in common clinical critical illnessCorresponding authors:PAN Longfei,Associate chief physician/Associate professor:E-mail:panlonf@yeah.netZHANG Guoqiang,Chief physician/Professor;E-mail:zhangchong 2003@vip.sina.comMA Yuefeng,Chiefphysician;E-mail:2193017@zju.edu.cnPEI Honghong,Chief physician:E-mail:18991237562@163.comAbstract Ulinastatin is mainly applied in the treatment of acute pancreatitis,but also in other common clinicalcritical illnesses such as shock,sepsis,evere pneumonia,cute respiratory distress syndrome,several acute poisoning,severeheat stroke,severe burns,severe trauma,and patients with sudden cardiac arrest for its roles in proteolytic enzymes inhibitionand inflammatory responses regulation,which has been recommended by several guidelines/expert consensus on the diagnose andtreatment of common clinical critical illness.However,there is currently a lack of consensus on the rational use of ulinastatin interms of indications,usage,dosage,and others.Therefore,in order to promote the standardized application of ulinastatin,theexpert group of expert consensus on the application of ulinastatin in common clinical critical illness summarized the mechanism,pharmacokinetics,indications of ulinastatin and its application methods in the treatment of common clinical critical illness,inorder to provide a reference for the rational application of ulinastatin in clinical practice.[Key words Emergency and critical diseases;Ulinastain;Expert consensus;Acute pancreatitis;Shock;Sepsis;Severe pneumonia;Acute respiratory distress syndrome;Acute poisoning;Severe heat stroke;Severe burns;Severe trauma;Cardiac arrest乌司他丁由健康人新鲜尿液提取，具有抑制多种国际实践指南注册号：PGRP-2022CN400蛋白水解酶、稳定溶酶体膜、保护血管内皮、改善通信作者：潘龙飞，副主任医师，副教授；E-mail:panlonf@微循环、减少细胞调亡、调控炎症反应、调节免疫yeah.net张国强，主任医师，教投；E-mail:zhangchong2003@vip.sin功能等作用，已被广泛用于治疗急性胰腺炎。基于com其作用机制，乌司他丁近年来的应用范围逐渐扩展至马岳峰，主任医师；E-mail:2193017@ed山cm休克、脓毒症、重症肺炎、急性呼吸窘迫综合征(acute裴红红，主任医师；E-mail:18991237562@163.c
