网络首发时间：2023-04-2417：1622网络首发地址：https:/kns.cnki.net/kcms/detail/13.1222.R.20230424.1019.002.html中国全科医学http/hewne.chinagpnet E-mail-agqkyx(@chinagp.net.en1·从指南到实践·预防老年抑郁症复发的最佳证据总结查侨侨2，徐莲英，陈娟，黄闻'，章新琼”【摘要】背景老年抑郁症复发率高，但目前国内外较缺乏预防老年抑郁症复发干预方案的研究。课题组前期探究了老年抑郁症复发的危险因素，其中可控性危险因素为服药依从性差、活动少、进食少。目的根据以上3个危险因素检索、评价和总结预防老年抑郁症复发的相关证据。方法2022年10月，计算机检索W山of Science、PubMed、Cochrane Library、美国指南网、英国指南库、加拿大安大略护理学会网站(RNAO)、复旦大学循证护理中心、中国知网等数据库，收集关于预防老年抑郁症和老年疾病伴发抑郁症复发方面的相关证据，包括指南、系统评价、专家共识、证据总结等，检索时限为从建库至2022年10月。由接受过循证医学系统培训的研究者分别采用指南研究与评价工具Ⅱ(AGREEⅡ)、AMSTAR、澳大利亚乔安娜布里格斯研究所(JBI)循证中心评价标准(2016版)对纳入的指南、系统评价、专家共识和原始研究进行质量评价。最后采用2014年澳大利亚版本JBI循证卫生保健中心证据分级及证据推荐级别系统进行证据汇总、评价和等级划分。结果共纳入15篇文献，包括指南3篇、系统评价11篇、随机对照实验1篇。纳入的3篇指南文献质量评价均为B级及以上，11篇系统评价文献质量评价均为中等质量及以上，1篇随机对照试验质量等级评定为B级。分别从干预评估、饮食与营养、运动与康复训练、社会心理干预、服药依从性、效果评价6个方面共汇总24条最佳证据。结论本研究总结了预防老年抑郁症复发的最佳证据，提示临床医护人员应全面评估患者，并结合患者和其疾病的特点，围绕评估、饮食与营养、运动与康复训练、服药依从性指导、社会心理干预等内容制定个体化干预方案。【关键词】抑郁症；复发；老年人；老年人保健服务；循证医学【中图分类号】R749.41【文献标识码】AD0L:10.12114.issn.1007-9572.2022.0727【引用本文】查倩倩，徐莲英，陈娟，等.预防老年抑郁症复发的最佳证据总结[J].中国全科医学，2023.[Eubahead of print DOI:10.12114/j.issn.1007-9572.2022.0727.www.chinagp.netZHA QQ,XU L Y,CHEN J,et al.Summary of best evidence for prevention of recurrence of late-life depression [J ]Chinese General Practice,2023.Epub ahead of printSummary of Best Evidence for Prevention of Recurrence of Late-life Depression ZHA Qiangian'2,XU Lianying',CHEN Juan',HUANG Wen',ZHANG Xingiong"1.Affiliated Psychological Hospital of Anhui Medical University (Anhui Mental Health Center),Hefei 230032,China2.School of Nursing,Anhui Medical University,Hefei 230032,ChinaCorresponding author:ZHANG Xingiong,Professor/Master supervisor;E-mail:hixqzhang@163.comAbstract Background The recurrence rate of late-life depression is high,however,there is a lack of researchon intervention protocol to prevent recurrence of late-life depression at home and abroad.In the early stage,the research groupexplored the risk factors for recurrence of late-life depression,and the controllable risk factors were poor medication compliance,less physical activity,and less eating.Objective To search,evaluate and summarize the evidence related to the prevention ofrecurrence of late-life depression based on the above three risk factors.Methods In October 2022,the evidences related to theprevention of recurrence of late-life depression were searched in Web of Science,PubMed,Cochrane Library,American GuideNetwork,British Guidebook,Wehsite of Registered Nurses Association of Ontario (RNAO),Evidence-based Nursing Centerof Fudan University,CNKI and other databases from inception to October 2022,which include guidelines,systematic reviews,expert consensuses,evidence summaries,etc.The quality of the included guidelines,systematic reviews,expert consensusesand original researches were evaluated by investigators trained in systematic evidence-based medicine using the Appraisal of基金项目：国家重点研究计划项目(2020Y℉C2008802】一一面向全媒体的老年健康大数据知识库和老年健康自主管理方法研究：2018年省级校企合作项目(2018sid056);合肥市第四人民医院科研项目(FSY202116
