*专家共识*《德港展o年2第出专第山期01子宫内膜未分化/去分化癌诊治的中国专家共识(2022年版)中国医师协会微无创医学专业委员会妇科肿瘤学组，中国医院协会妇产医院分会妇科肿瘤专业学组，中国优生科学协会肿瘤生殖学分会精要：子宫内膜未分化癌(UEC)是一种实体肿瘤，无特异性上皮分化的形态学证据：子宫内膜去分化癌(DEC)由低级别子宫内膜样腺癌与UEC成分组成，且每种成分至少占肿瘤体积的10%。UEC/DEC少有雄藏素受体/孕激素受体的表达，侵袭性强，确诊时多为晚期，预后差。鉴于UEC/DEC存在组织病理学、基因生物学的较明显异质性以及治疗困难等特殊性，且目前国内外缺乏独立的临床指南、共识及前瞻性临床试验，中国医师协会微无创医学专业委员会妇科肿瘤学组、中国医院协会妇产医院分会妇科肿瘤专业学组、中国优生科学协会肿瘤生殖学分会通过全面检索国内外相关文献，按照推荐分级的评估、指定与评价标准评估证据质量和推荐强度，联合制定本共识，旨在总结既往有关报道及研究成果，以期为UEC/DEC的诊断和治疗提供借鉴。关健词：子宫内膜癌：子宫内膜未分化/去分化癌：诊断：治疗：专家共识中图分类号：R737.33文献标志码：Adoi:10.118776.issn.1672-1535.2023.21.01.01Expert consensus on diagnosis and treatment of undifferentiated/dedifferentiatedendometrial carcinoma (2022 Edition)AGynecologic Oncology Group,Minimally Noninvasive Medical Professional Committee of Chinese Medical Doctor Association,GynecologicOncology Specialty Group ofObstetrics and Gynecology Hospital Branch of Chinese Hospital Association,Cancer Reproduction Branch ofthe Chinese Eugenics Science AssociationAbatract:Undifferentiated endometrial carcinoma (UEC)is a solid tumor with no morphological evidence of specificepithelial differentiation.Dedifferentiated endometrial carcinoma (DEC)consists of low-grade endometrioid adenocarci-noma and UEC components,each of which accounts for at least 10%of the tumor volume.UEC/DEC has little estrogenreceptor (ER)progesterone receptor (PR)expression,and is highly invasive.It is usually diagnosed at a late stage and haspoor prognosis.In view of the histopathology,heterogeneity in gene biology and difficulties in treatment of UEC/DECand the lack of independent clinical guidelines,consensus and prospective clinical trials at home and abroad,the Gyneco-logic Oncology Group,Minimally Noninvasive Medical Professional Committee of Chinese Medical Doctor Association,Gynecologic Oncology Specialty Group of Obstetrics and Gynecology Hospital Branch of Chinese Hospital Association,Cancer Reproduction Branch of the Chinese Eugenics Science Association comprehensively searched the relevant litera-ture at home and abroad,this consensus was jointly developed based on the assessment of recommendation grading,desig-nation and evaluation criteria of the evidence quality and recommendation strength with the intention to summarize previ-ous reports and research findings,and provide reference for the diagnosis and treatment of UEC/DEC.Key words:endometrial cancer;undifferentiated/dedifferentiated endometrial carcinoma;diagnosis;treatment;ex-pert consensusOncol Prog.2023,21(1)子宫内膜癌(endometrial carcinoma,EC)是最低分化(G,级)高级别子宫内膜样癌(high-grade en-常见的妇科恶性肿瘤之一，据2020年国家癌症中dometrial carcinoma,HGEC)占I%,非子宫内膜样心数据统计，其发病率为10.54/10万，居中国女性癌占29%，其中子宫内膜浆液性癌、子宫内膜透明生殖系统恶性肿瘤第二位四。2013年癌症基因组细胞癌和UEC分别占13%、7%、9%)，UEC的发病图谱(The Cancer Genome Atlas,TCGA)提出新的率高于子宫内膜透明细胞癌，必须引起高度重视，EC分子分型策略，对临床实践产生深远影响，但未这也是本共识制定的出发点。涉及子宫内膜未分化/去分化癌(undifferentiated/.de2020年世界卫生组织(WHO)第5版女性生殖differentiated endometrial carcinoma,UEC/DEC)l系统肿瘤分类，将UEC纳入子宫内膜上皮肿瘤和MD Anderson癌症中心的一项回顾性研究发现，前驱病变的分类命名中[目录及疾病编码（未分化高/中分化(G/G2级)低级别子宫内膜样癌(1ow癌，NOS
