Journal ofAntimicrobialJ Antimicrob Chemotherhttps://doi.org/10.1093/jac/dkad143ChemotherapyPrimary prophylaxis of invasive fungal diseases in patients withhaematological malignancies:2022 update of the recommendations ofthe Infectious Diseases Working Party (AGIHO)of the German Societyfor Haematology and Medical Oncology (DGHO)Jannik Stemler 12.3,Sibylle C.Mellinghoff 12.3,Yascha Khodamoradi 4,Rosanne Sprute 12.3,Annika Y.Classen Sonja E.Zapkes,Martin Hoenigl,Robert Krause,Martin Schmidt-Hieber,Werner J.HeinzMichael Klein,Philipp Koehler,Blasius Liss10,Michael KoldehoffChristoph Buhl3,Olaf Penack15,Georg Maschmeyer6,Enrico Schalk7,Comnelia Lass-FlorlMeinolf Karthaus,Markus Ruhnke2,Oliver A.Cornely 1,.2122 and Daniel Teschner2.24University of Cologne,Faculty of Medicine and University Hospital Cologne,Department I of Intemal Medicine,Excellence Center forMedical Mycology (ECMM),Cologne,Germany;University of Cologne,Faculty of Medicine and University Hospital Cologne,TranslationalResearch,Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD),Cologne,Germany;3GermanCentre for Infection Research(DZIF),Partner Site Bonn-Cologne,Cologne,Germany;"Department of Internal Medicine,InfectiousDiseases,University Hospital Frankfurt,Goethe University Frankfurt,Frankfurt am Main,Germany;Department Hematology,Oncology,Infectious disease and Palliatve Care,Helios University Hospital Wuppertal,Wuppertal,Germany,5Division of Infectious Diseases,Department of Internal Medicine,Excellence Center for Medical Mycology (ECMM),Medical University of Graz,Graz,Austria andBioTechMed,Graz,Austria;2nd Medical Clinic (Hematology,Oncology,Pneumology,Nephrology),Carl-Thiem Clinic Cottbus,Cottbus,Germany;Medical Clinic II,Caritas Hospital,Bad Mergentheim,Germany,Department of Hematology and Medical Oncology,KlinikumVest,Knappschaftskrankenhaus,Recklinghausen,Germany,school of Medicine,Faculty of Health,Witten/Herdecke University,Witten,Germany;Department of Bone Marrow Transplantation,West German Cancer Center,University Hospital Essen,University of Duisburg-Essen,Essen,Germany;Department of Hygiene and Environmental Medicine,University Hospital Essen,University of Duisburg-Essen,Essen,Germany;Medical Clinic II,Hospital Leverkusen,Leverkusen;Charite-Universitatsmedizin Berlin,Corporate Member of FreieUniversitat Berlin,Berlin,Germany;15Humboldt-Universitat zu Berlin,Department of Hematology,Oncology and Tumorimmunology,Berlin,Germany;Formerly Department of Hematology,Oncology and Palliative Care,Klinikum Ernst von Bergmann,Potsdam,Germany;17Department of Haematology and Oncology,Medical Centre,Otto-von-Guericke University Magdeburg,Magdeburg,Gemanynstitute of Hygieneand MedicalMicrobiology,ECMM Excellence Centre,Medical Universityof Insbruck,Innsbruck,Austria;1Department of Hematology,Oncology and Palliative Care,Klinikum Neuperlach,Munich,Germany;2Helios Klinikum Aue,Klinik furHamatologie/Onkologie Palliativmedizin,Aue,Germany;21 Universit