2022专家共识：再生性牙髓治疗

International Journal of Oral Sciencewww.nature.com/ijosREVIEW ARTICLEOPENExpert consensus on regenerative endodontic proceduresXi Wei,Maobin Yang2,Lin Yue3,Dingming Huang",Xuedong Zhou",Xiaoyan Wang,Qi Zhang',Lihong Qiu,Zhengwei Huang',Hanguo Wang3,Liuyan Meng,Hong Li1o,Wenxia Chen'1,Xiaoying Zou3 and Junqi LingRegenerative endodontic procedures(REPs)is a biologic-based treatment modality for immature permanent teeth diagnosed withpulp necrosis.The ultimate objective of REPs is to regenerate the pulp-dentin complex,extend the tooth longevity and restore thenormal function.Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports,case series,cohort studies,and randomized controlled studies.However,variations in clinical protocols for REPs exist due to theempirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics.Theheterogeneity in protocols may cause confusion among dental practitioners,thus guidelines and considerations of REPs should beexplicated.This expert consensus mainly discusses the biological foundation,the available clinical protocols and current status ofREPs in treating immature teeth with pulp necrosis,as well as the main complications of this treatment,aiming at refining theclinical management of REPs in accordance with the progress of basic researches and clinical studies,suggesting REPs may becomea more consistently evidence-based option in dental treatment.International Journal of Oral Science (2022)14:55;http5/doi.org/10.1038/541368-022-00206-zINTRODUCTIONIn 2004,Banchs and Trope'reported a case with a modifiedPulpal and periradicular pathosis,which can be caused by caries,protocol of revascularization,specifically creating a blood clot intrauma,or dental abnormalities,is a common disease in clinic forthe canals after disinfection as a matrix for new tissue growth anddental treatment.Root canal treatment (RCT)is a conventionala bacterial-tight coronal seal to prevent bacterial invasion into theoption to manage the endodontic diseases in fully developedpulp space,providing evidence for clinical application ofpermanent teeth demonstrating outstanding dlinical outcomes,regenerative endodontics.while apexification procedure is the traditional treatment modalityCurrently,strategies of regenerative endodontics mainly involvefor the immature permanent teeth with pulp necrosis.12 Thestem cell transplantation,cell homing and regenerative endodon-purpose of endodontic treatment is to eliminate pulp andtic procedures(REPs).-1 Stem cell transplantation was reportedperiapical inflammation/infection and preserve the teeth.How-to successfully regenerate the pulp tissue in dinic,while only REPsever,these treatment procedures remove the pulp and somehas been widely applied in clinical practice.REPs is a biologicallydentin tissues,which weaken the dentinal strength,immunologi-based approach incorporating the concept of tissue engineerin