ARTICLE IN PRESSFROM THE ACADEMYGuidelines of care for the managementof atopic dermatitis in adults withtopical therapiesRobert Sidbury,MD,MPH,Co-Chair,*Ali Alikhan,MD,Lionel Bercovitch,MD,David E.Cohen,MD,MPH,Jennifer M.Darr,LCSW,Aaron M.Drucker,MD,ScM,Lawrence E Eichenfield,MD,Lindsy Frazer-Green,PhD,'Amy S.Paller,MD,Kathryn Schwarzenberger,MD,Jonathan I.Silverberg,MD,PhD,MPH,'Anne Marie Singh,MD,Peggy A.Wu,MD,MPH,"andDawn M.R.Davis.MD.Co-ChairBackground:New evidence has emerged since the 2014 guidelines that further informs the managementof atopic demmatitis (AD)with topical therapies.These guidelines update the 2014 recommendations formanagement of AD with topical therapies.Objective:To provide evidence-based recommendations related to management of AD in adults usingtopical treatments.Metbods:A multidisciplinary workgroup conducted a systematic review and applied the GRADE(Gradingof Recommendations,Assessment,Development,and Evaluations)approach for assessing the certainty ofevidence and formulating and grading recommendations.Results:The workgroup developed 12 recommendations on the management of AD in adults with topicaltherapies,including nonprescription agents and prescription topical corticosteroids (TCS),calcineurininhibitors(TCIs),Janus kinase (JAK)inhibitors,phosphodiesterase-4 inhibitors(PDE-4),antimicrobials,andantihistamines.Limitations:The pragmatic decision to limit the literature review to English-language randomized trialsmay have excluded data published in other languages and relevant long-term follow-up data.From the Division of Dermatology,Department of Pediatrics,Funding sources:This study was funded in total by internal fundsUniversity of Washington School of Medicine and Seattlefrom the American Academy of Dermatology.Children's Hospital,Seattle,Washington;Department ofIRB approval status:Not applicable.Dermatology,Sutter Medical Foundation,Sacramento,Califor-Disclaimer:Adherence to these guidelines will not ensure suc-nia;Department of Dermatology,Warren Alpert Medicalcessful treatment in every situation.Furthermore,these guide-School of Brown University,Providence,Rhode IslandS Thelines should not be interpreted as setting a standard of care orRonald O.Perelman Department of Demmatology,New Yorkbe deemed inclusive of all proper methods of care,norUniversity Grossman School of Medicine,New York,New Yorka,exclusive of other methods of care reasonably directed toDepartment of Pediatrics,National Jewish Health,Denver,obtaining the same results.The ultimate judgment regardingColorado;Division of Dermatology,Department of Medicine,the propriety of any specific therapy must be made by theUniversity of Toronto,Toronto,Ontario,Canada;Women'sphysician and the patient in light of all the circumstancesCollege Research Institute,Women's College Hospital,Toronto,presented by the individual patient,and the known variabilityOntario,Canada9;University of Califomia San Diego andand biologic behavior of the disease.This guideline reflect
