2023AGI共识建议：共济失调的MR成像

The Cerebellumhttp5/doi.org/10.1007/s12311-023-01572-yREVIEWMR Imaging in Ataxias:Consensus Recommendations by the AtaxiaGlobal Initiative Working Group on MRI BiomarkersGulin Oz'.Sirio Cocozza2.Pierre-Gilles Henry'.Christophe Lenglet'.Andreas Deistung3.Jennifer Faber45.AdamJ.Schwarz5.Dagmar Timmann7.Koene R.A.Van Dijk.lan H.Harding0.on behalf ofthe AGIWorkingGroup on MRI BiomarkersAccepted:18 May 2023©The Author(s)2023AbstractWith many viable strategies in the therapeutic pipeline,upcoming clinical trials in hereditary and sporadic degenerativeataxias will benefit from non-invasive MRI biomarkers for patient stratification and the evaluation of therapies.The MRIBiomarkers Working Group of the Ataxia Global Initiative therefore devised guidelines to facilitate harmonized MRI dataacquisition in clinical research and trials in ataxias.Recommendations are provided for a basic structural MRI protocol thatcan be used for clinical care and for an advanced multi-modal MRI protocol relevant for research and trial settings.Theadvanced protocol consists of modalities with demonstrated utility for tracking brain changes in degenerative ataxias andincludes structural MRI,magnetic resonance spectroscopy,diffusion MRI,quantitative susceptibility mapping,and resting-state functional MRI.Acceptable ranges of acquisition parameters are provided to accommodate diverse scanner hardwarein research and clinical contexts while maintaining a minimum standard of data quality.Important technical considerationsin setting up an advanced multi-modal protocol are outlined,including the order of pulse sequences,and example softwarepackages commonly used for data analysis are provided.Outcome measures most relevant for ataxias are highlighted withuse cases from recent ataxia literature.Finally,to facilitate access to the recommendations by the ataxia clinical and researchcommunity,examples of datasets collected with the recommended parameters are provided and platform-specific protocolsare shared via the Open Science Framework.Keywords MRI biomarkers.Structural MRI.Magnetic resonance spectroscopy.Diffusion MRI.Quantitativesusceptibility mapping.Functional MRI☒Gulin Oz5Department of Neurology,University Hospital Bonn,Bonn,gulin@cmrr.umn.eduGermany6Center for Magnetic Resonance Research,DepartmentTakeda Pharmaceuticals Ltd.,Cambridge,MA.USAof Radiology,University of Minnesota,2021 Sixth StreetDepartment of Neurology and Center for TranslationalSoutheast,Minneapolis,MN 55455,USANeuro-and Behavioral Sciences (C-TNBS).Essen UniversityUNINA Department of Advanced Biomedical Sciences,Hospital,University of Duisburg-Essen,Essen,GermanyUniversity of Naples Federico II,Naples,ItalyDigital Sciences and Translational Imaging.Early ClinicalDepartment for Radiation Medicine,University ClinicDevelopment,Pfizer.Inc.,Cambridge,MA.USAand Outpatient Clinic for Radiology.University HospitalDepartment of Neuroscience,Central Clinical School.Halle (Saale).Halle (Saale).GermanyMonash University,Melb