ARTICLE IN PRESSTransplantation and Cellular Therapy■■(2023)■■■-■■■Transplantation andCellular TherapyASTCTAmerican Society forTransplantation and Cellular TherapyELSEVIERjournal homepage:www.astctjournal.orgEvaluation of Children with Malignancies for Blood and MarrowTransplantation:A Report from the ASTCT Committee on PracticeQ1Guidelines02Ellen Fraint*,Hisham Abdel-Azim2,Neel S.Bhatt,Larisa Broglie4,Asma Chattha,Mira KohorstYiouli P.Ktena Michelle A.Lee',Susie Longs,Muna Qayed,Akshay Sharma,Heather Stefanski1Anant Vatsayan2,Lisa Wray3,Mehdi Hamadani14,Paul A.CarpenterDivision of Pediatric Hematology,Oncology,and Cellular Therapy,Children's Hospital at Montefiore,Bronx,New York2Loma Linda University Schoolof Medicine,Cancer Center,Children's Hospital and Medical Center,Loma Linda,Cahfornia3Clinical Research Division,Fred Hutchinson Cancer Center,Seattle,WashingtonMedical College of Wisconsin,Department ofPediatrics,Division of Pediatric Hematology/Oncology/Blood and Marrow Transplantation,Milaukee.Wisconsin5Department of Pediatric and Adolescent Medicine,Mayo Clinic,Rochester,MinnesotaDepartment of Pediatric and Adolescent Medicine,Division of Pediatric HematologyOncology,Mayo Clinic,Rochester,MinnesotaDepartment of Oncology.Sidney Kimmel Comprehensive Cancer Center.Johns Hopkins School of Medicine,Baltimore,MarylandUniversity of Minnesota Masonic Children's Hospital MHealth Fairview Acute Care Phamacy Services Minneapolis,MinnesotaAflac Cancer and Blood Disorders Center,Emory University and Children's Healthcare of Atlanta,Atlanta,GeorgiaDepartment ofBone Marrow Transplantation and Cellular Therapy,St jude Children's Research Hospital Memphis,TennesseeNationalMarrow Donor Program,Minneapolis,MinnesotaChildren'sNational Medical Center,Washington,District of ColumbiaBMT&Cellular Therapy Program.Department of Medicine,Medical College of Wisconsin,Milwaukee,WisconsinArticle history:ABSTRACTReceived 3 February 2023Evaluation of a candidate for hematopoietic cell transplantation (HCT)is a complex process with substantial inter-Accepted 3 February 2023center variability.Although literature providing guidance for evaluating the eligibility of adults is well established,similar guidance for children is lacking.To address gaps between adult recommendations and the specific needs ofKey Words:children,we convened a panel of pediatric HCT experts from a wide geographic range of American Society ofPediatric hematopoietic cellTransplantation and Cellular Therapy (ASTCT)member institutions to offer recommendations for pediatric-transplantationfocused pre-HCT evaluation.In this report from the ASTCT Committee on Practice Guidelines,we present a practi-Pretransplantation evaluationcal framework for evaluating children with malignancies who are candidates for HCT.We also highlight key differ-Q3Pediatric malignancyences from adults and emphasize areas of unmet need that require additional research to delineate best practices.Transplantation candidate2023 Publishe
