真Check for updatesReceived:3 March 2023 Accepted:20 March 2023D0t10.1002/j5a.27269REVIEW ARTICLESURGiCAL ONCOLOGWILEYBrazilian Society of Surgical Oncology:Guidelinesfor the management of anal canal cancerMarcus Valadao MD,PhD1 Rachel P.Riechelmann MD,PhD2Jose Antonio Cunha e Silva MD,MSc3 Jorge Mali Jr,MD,PhD4Bruno Azevedo MD5 Samuel Aguiar MD,PhD5 Rodrigo Araujo MD,PhD1Mario Feitoza MD?Eid Coelho MD3 Arthur Accioly Rosa MD?Naomi Jay PhD10 Alexcia Camila Braun PhD7Rodrigo Pinheiro MD,PhD11 Heber Salvador MD,PhD6Department of Abdomino-Pelvic Surgery.Instituto Nacional de Cancer,Rio de Janeiro.AbstractBrazilBackground:Anal canal squamous cell carcinoma (SCC)is a relatively uncommon2Department of Clinical Oncology.ACCamargo Cancer,CenterSao Paulo,Brazilneoplasia,and it is mostly a local-regional cancer,of low metastatic potential (only3Department of Surgery.Hospital15%),resulting in cure in most cases treated with definitive chemoradiation.On theUniversitario Antonio Pedro,Niteroi,Brazilother hand,its incidence has been steadily increasing over the last decades,whichDepartment of Surgery.Hospital do Cancermakes it an important public health problem.In an effort to provide surgeons andde Londrina,Londrina,Brazil5Department of Surgical Oncology.Grupooncologists who treat patients with anal cancer with the most updated informationOncoclinicas,Curitiba,Brazilbased on the best scientific evidence,the Brazilian Society of Surgical OncologyDepartment of Surgical Oncology.AC(SBCO)has produced the present guideline for the management of anal canal SCC,Camargo Cancer,CenterSao Paulo,Brazilfocused on the main topics related to daily clinical practice.Brazilian Society of Surgical Oncology,Rio deJaneiro,BrazilObjectives:The SBCO developed the present guidelines to provide recommenda-Department of Surgery.Hospital So Marcos.tions on the main topics related to the management of anal canal squamous cellTeresina,Brazilcarcinoma(SCC)based on current scientific evidence.Department of Radiation Oncology.Methods:Between October 2022 and January 2023,14 experts met to develop theOncoclinicas Salvador-Hospital Santa lzabel,Salvador,Brazilguidelines for the management of anal canal cancer.A total of 30 relevant topicssan Francisco School of Medicine.were distributed among the participants.The methodological quality of a final listUniversity of California,San Francisco.with 121 sources was evaluated,all the evidence was examined and revised,and theCalifomia,USADepartment of Surgical Oncology.Hospitalmanagement guidelines were formulated by the 14-expert committee.To reach ade Base do Distrito Federal,Brasilia,Brazilfinal consensus,all the topics were reviewed in a meeting that was attended by allthe experts.CorrespondenceMarcus Valadao,MD.PhD,Department ofResults:The proposed guidelines contained 30 topics considered to be highlyAbdomino-Pelvic Surgery.Instituto Nacionalrelevant in the management of anal canal cancer,covering subjects related tode Cancer,Rio de Janeiro,Br
