2023DNG指南：短暂性全面性遗忘症(TGA)

Sander etalNeurological ResearchNeurological Research and Practice2023)5:15http5/dol.org/10.1186542466-023-00240-0and PracticeGUIDELINESOpen AccessGuideline"Transient Global Amnesia(TGA)"eck fd1Cof the German Society of Neurology(DeutscheGesellschaft fur Neurologie):S1-guidelineDirk Sander,Thorsten Bartsch2,Florian Connolly3,Christian Enzinger,Urs Fischer5,Nils Nellesen5,Holger Poppert?,Kristina Szabos and Helge TopkaAbstractIntroduction In 2022 the DGN(Deutsche Gesellschaft fur Neurologie)published an updated Transient Global Amne-sia (TGA)guideline.TGA is characterized by a sudden onset of retrograde and anterograde amnesia for a period of oneto a maximum of 24 h(with an average of 6 to 8 h).The incidence is estimated between 3 and 8 per 100,000 popula-tion/year.TGA is a disorder that occurs predominantly between 50 and 70 years.Recommendations The diagnosis of TGA should be made clinically.In case of an atypical clinical presentation or sus-picion of a possible differential diagnosis,further diagnostics should be performed immediately.The detection of typi-cal unilateral or bilateral punctate DWI/T2 lesions in the hippocampus (especially the CA1 region)in a proportion ofpatients proves TGA.The sensitivity of MRI is considered higher when performed between 24 and 72 h after onset.Ifadditional DWI changes occur outside the hippocampus,a vascular etiology should be considered,and prompt sono-graphic and cardiac diagnostics should be performed EEG may help to differentiate TGA from rare amnestic epilepticattacks,especially in recurrent amnestic attacks.TGA in patients<50 years of age is a rarity,therefore it is mandatory torapidly search for other causes in particular in younger patients.The cause of TGA is still unknown.Numerous findingsin recent years point to a multifactorial genesis.Because the pathomechanism of TGA is not yet clearly known,noevidence-based therapeutic or prophylactic recommendations can be made.Conclusions There is no evidence for chronic sequelae of TGA with respect to cerebral ischemia,chronic memoryimpairment,or the onset of dementia-related syndromes.Keywords Amnesia,Transient,Memory impairment,Hippocampus,Differential diagnosisThis guideline is a short translated version of the German guidelineNeurologische Universitatsklinik,Medizinische Universitat Graz,Graz,"Transiente globale Amnesie.A complete version of this guideline (inAustriaGerman)can be found on the website of the Deutsche Gesellschaft fur5 Neurologische Universitat sklinik,Universitatsspital Basel BaselNeurologie (wwwdgn.org/leitlinien)and the AWMF (ArbeitsgemeinschaftSwitzerlandwissenschaftlicher Medizinischer Fachgesellschaften).Klinik fur Neurologie und Neurophysiologie,Helios UniversitatsklinikumCorrespondence:Wuppertal Universitat Witten-Herdecke,Wuppertal GermaryNeurologische Klinik,Helios Klinikum Munchen West,Munich,GermanyDirk SanderDSander@maccomNeurologische Klinik,Universitatsmedizin Mannheim,MedizinischeFakultat der Universitat Heidelberg,Mannhei