ESCEuropean Heart Journal (2023)00,1-15SPECIAL ARTICLEEuropean Society https://doiorg/10.1093/eurheart/ehad197of CardiologyDyslipidaemias2023 Update on European AtherosclerosisSociety Consensus Statement on HomozygousFamilial Hypercholesterolaemia:newtreatments and clinical guidanceMarina Cuchel Frederick J.Raal 2t,Robert A.Hegele3,Khalid Al-Rasadi 4,Marcello Arca5,Maurizio Averna5.7,Eric BruckertTomas Freiberger 9,Daniel Gaudet 10,Mariko Harada-Shiba11,Lisa C.Hudgins12,Meral Kayikcioglu 13,Luis Masana 14,Klaus G.Parhofer15,Jeanine E.Roeters van Lennep 1,Raul D.Santos 1718,Erik S.G.Stroes9Gerald F.Watts20,Albert Wiegman 21,Jane K.Stock22,Lale S.Tokgozoglu23,Alberico L.Catapano 24,and Kausik K.Ray 25Dvsionof Translational Medicine and Human Genetics.Department of Mediche.Perelman School of Medicine University of Pennsylvania9017 Maloney Building 3600 Spruce Street.Philadelphia PA 19104.USA:'Carbohydrate and Lipid Metabolism Research Unit.Division of Endocrinology and Metabolism.Department of Medicine Faculty of Health SciencesUniversity of the Witwatersrand Parktown,Johannesburg.South Africa Department of Medicine and Robarts Research Institute Schulich School of Medicine and Dentistry.WestemUniversity.London.Ontario,Canada:Department of Biochemistry.College of Medicine &Health Sciences.Medical Research Center.Sultan Qaboos University.Muscat.OmanDepartment of Transational and Precision Medicine.Sapierza University of Rome.Rome.taly:Department of Heath Promotion Scerces Matemal and Infantile Care.Interal Medicineand Medical Specialities University of Palemmo Palermo.Italy:'Istituto di Biofisica.Consiglio Nazionale delle Ricerche Genova Italy:Piti-Salpetrere Hospital and Sorbonne University.Cardio metabolic Institute Paris,France Centre for Cardiovascular Surgery and Transplantation,and Medical Faculty.Masaryk University.Brno.Czech RepublicClinical Lipidology andRare Lipid Disorders Unit.Community Genomic Medicine Center.Department of Medicine.Universite de Montreal ECOGENE.Oinical and Translational Research Center.and LipidOinic.Chicoutimi Hospital Chicoutimi Quebec.Canada:Cardiovascular Center.Osaka Medical and Phamaceutical University.Osaka apan:Rogosin Institute.Well Comell MedicalCollege.New York NY.USADepartment of Cardiology.Faculty of Medicine.Ege University.lzmir.Turkey:Vascular Medicine and Metabolism Unit Research Uniton Lipids andAtherosclerosis,Sant Joan University Hospital Universitat Rovira i Virgili IISPV CIBERDEM.Reus Spain:Medizinische Klinik und Polikdinik I.Ludwigs-Maximilians University Klinikum.Munich.Germany:Department of Internal Medicine Erasmus MC.Medical Center.Rotterdam The Netherlands:1Lipid Clinic,Heart Institute(InCor).University of Sto Paulo MedicalSchool Hospitalo Paulo.BraziAcademic Research Organization Hospita sraeita Albert Bnstein,Sao Paulo.BraziDepartment of Vascular Medicine Amsterdam CardiovascularSciences Amsterdam University Medical Centers.University of Amsterdam Amsterdam.The NetherlandsMedical School Uni
