ESCEuropean Heart Journal (2023)00,1-15SPECIAL ARTICLEEuropean Society https://doiorg/10.1093/eurheart/ehad197of CardiologyDyslipidaemias2023 Update on European AtherosclerosisSociety Consensus Statement on HomozygousFamilial Hypercholesterolaemia:newtreatments and clinical guidanceMarina Cuchel Frederick J.Raal 2t,Robert A.Hegele3,https:Khalid Al-Rasadi 4,Marcello Arca 5,Maurizio Averna 57,Eric Bruckert,/acaTomas Freiberger 9,Daniel Gaudet 10,Mariko Harada-Shiba 11Lisa C.Hudgins12,Meral Kayikcioglu 13,Luis Masana 14,Klaus G.Parhofer15,Jeanine E.Roeters van Lennep 1,Raul D.Santos 1718,Erik S.G.Stroes9Gerald F.Watts20,Albert Wiegman 21,Jane K.Stock22,Lale S.Tokgozoglu23,Alberico L.Catapano 24,and Kausik K.Ray 25Philadelphia PA 19104.USA:'Carbohydrate and Lipid Metabolism Research Unit.Division of Endocrinology and Metabolism.Department of Medicine Faculty of Health SciencesUniversity of the Witwatersrand Parktown,Johannesburg.South Africa Department of Medicine and Robarts Research Institute,Schulich School of Medicine and Dentistry.WestemUniversity.London,Ontario.of Biochemistry.College of Medicine Health Sciences,Medical Research Center.Sultan Qaboos University.Muscat.OmanDepartment of Translational and Precision Medicine.Sapienza University of Rome.Rome.Italy:Department of Health Promotion Scences Matemal and Infantile Care.Internal Medicineand Medical Speciallities,University of Palemmo,Palemmo.Italy:'Istituto di Biofisica.Consiglio Nazionale delle Ricerche Genova ltaly:Piti-Salpetrere Hospital and Sorbome Unversity.Cardio metabolic Institute Paris,France Centre for Cardiovascular Surgery and Transplantation,and Medical Faculty.Masaryk University.Brno.Czech RepublicClinical Lipidology andRare Lipid Disorders Unit.Community Genomic Medicine Center.Department of Medicine.Universite de Montreal ECOGENE,Oinical and Translational Research Center.and LipidOinic.Chicoutimi Hospital Chicoutimi Qubec.Canada:Cardiovasoular Center.Osaka Medical and Phamaceutical University.Osaka apanRogosin Institute,Weill Comell MedicalCollege.New York NY.USADepartment of Cardiology.Faculty of Medicine.Ege University.lzmir.Turkey:Vascular Medicine and Metabolism Unit Research Uniton Lipids andAtherosclerosis,Sant Joan University Hospital Universitat Rovira i Virgili IISPV CIBERDEM,Reus Spain Medizinische Klinik und Polikdinik I.Ludwigs-Maximilians University Klinikum,1093Munich.Germany:Department of Internal Medicine.Erasmus MC.Medical Center.Rotterdam The Netherlands:1Lipid Clinic.Heart Institute(InCor).University of Sto Paulo MedicalSchool Hospital So Paulo,BrazilAcademic Research Organization Hospital sraelita Albert Bnstein,Sao Paulo,BrazitDepartment of Vascular Medicine Amsterdam CardiovascularSciences Amsterdam University Medical Centers.University of Amsterdam Amsterdam.The NetherlandsMedical School University of Western Australia,and Department ofCardiology.Lipid Disorders Clinic.Royal Perth Hospital Perth,Australia:Department of Pediatrics.Amsterdam University