FACTS VIEWs VIs OBGYN.2023,15 (1):3-23shrepeen soaery tC WOVNESGE pagesESGO/ESHRE/ESGE Guidelines for the fertility-sparing treatmentof patients with endometrial carcinoma*tA.RODOLAKIS',G.SCAMBIA2,F.PLANCHAMP3,M.ACIEN,A.DI SPIEZIO SARDO,M.FARRUGIA,M.GRYNBERG79,M.PAKI210,K.PAVLAKIS1,12,N.VERMEULEN,G.ZANNONI4,I.ZAPARDIELI5,K.L.TRYDE MACKLON!6Unit of Gynaecologic Oncology,Alexandra Hospital,National and Kapodistrian University of Athens School of HealthSciences,Athens,Greece;"Fondaione Policlinico Universitario A.Gemelli IRCCS-Universita Cattolica del SacroCuore,Roma,Italy;Clinical Research Unit,Institut Bergonie,Bordeax,France;'Obstetrics and Gynecology Depart-ment,San Juan University Hospital,Miguel Hernandez University,Alicante,Spain;5Gynecology and Obstetrics Unit,Department of Public Health,School of Medicine,University of Naples Federico II,Napoli,Campania,Italy;"SpencerPrivate Hospitals,East Kent,UK;'AP-HP,Department of Reproductive Medicine Fertility Preservation,HopitalAntoine-Beclere,Clamart,France;"AP-HP,Department of Reproductive Medicine Fertility Preservation,HopitalJean Verdier,Bondy,France;"University Paris-Saclay,Saint-Aubin,France;Department for Gynecologic and BreastOncology,University Medical Centre,Maribor,Slovenia;"Ist Pathology Department,Alexandra Hospital,National andKapodistrian University of Athens School of Health Sciences,Athens,Greece;"Pathology Department,"IASO"Women'sHospital.Athens,Greece;European Society of Human Reproduction and Embryology.Strombeek-Bever.Belgium;Department of Pathology,Dipartimento Scienze della Salute della Donna e del Bambino e di Sanita Pubblica,Fon-daione Policlinico Universitario Agostino Gemelli IRCCS Rome,Italy:Department ofGynecologic Oncology,La Pa=University Hospital,Madrid Spain;"Fertility Department,Copenhagen University Hospital,Copenhagen,Denmark.Correspondence at:Alexandros Rodolakis,Unit of Gynaecologic Oncology,Alexandra Hospital,National and Kapodis-trian University of Athens School of Health Sciences,Athens 115 28,Greece.E-mail:a.rodolaki@gmail.comAbstractBackground:The standard surgical treatment of endometrial carcinoma (EC)consisting of total hyste rectomywith bilateral salpingo-oophorectomy drastically affects the quality of life of patients and creates a challengefor clinicians.Recent evidence-based guidelines of the European Society of Gynaecological Oncology(ESGO),the European SocieTy for Radiotherapy Oncology (ESTRO)and the European Society of Pathology (ESP)provide comprehensive guidelines on all relevant issues of diagnosis and treatment in EC in a multidisciplinarysetting.While also addressing work-up for fertility preservation treatments and the management and follow-upfor fertility preservation,it was considered relevant to further extend the guidance on fertility sparing treatment.Objectives:To define recommendations for fertility-sparing treatment of patients with endometrial carcinoma.Materials and Methods:ESGO/ESHRE/ESGE nominated an international multidisciplin
