Radiotherapy and Oncology 184 (2023)109663Contents lists available at Science DirectRadiotherapy and OncologyELSEVIERjournal homepage:www.thegreenjournal.comOriginal ArticleESTRO-EANO guideline on target delineation and radiotherapy details forglioblastomapMaximilian Niyazi a.b.c.*,Nicolaus Andratschke d,Martin Bendszus e,Anthony J Chalmers,Sara C ErridgeNorbert Galldiksh,Frank Lagerwaard,Pierina Navarria,Per Munck af Rosenschold",Umberto RicardiMartin J van den Bent,Michael WellerP,Claus Belka..c,Giuseppe MinnitiDepartment of Radiation Oncology,University Hospital LMU Munich:German Cancer Consortium (DKTK),partner site Munich:Bavarian Cancer Research Center(BZKF),Munich,Germany:Department of Radiation Oncology,University Hospital Zurich,University of Zurich,Zurich,Switzerland:Department of Neuroradiology.University Hospital Heidelberg.Heide lberg.Gemany.'School of Cancer Sciences,University of Glasgow.Glasgow G61 1QH:Edinburgh Centre for Neuro-Oncology.University of Edinburgh,Western GeneralHospital Edinburgh EH4 1EU.UK:Department of Neurology.Faculty of Medicine.University Hospital Cologne.University of Colgne.Cologne:Istitte of Neuroscience andMedicine (INM-3).Research Center Juelich,Juelich:Center for Integrated Oncology (CO).Universities of Aachen,Bonn,Cologne,and Duesseldorf.Germany:Department of RadiationOncology,Amsterdam UMC location Vrije Universiteit Amsterdam,the NetherlandsRadiotherapy and Radiosurgery Department,IRCCS,Humanitas Research Hospital,Rozzana Ml.ltaly:"Radiation Physics Department of Hematology,Oncology and Radiation Physics Skine University Hospital,and Lund University.Lund,Sweden:"Department of OncologyUniversity of Turin,Turin,Italy:Erasmus MC Cancer Institute,Rotterdam,the Netherlands:P Department of Neurology.Clnical Neuroscience Center.University Hospital andUniversity of Zurich,Zurich,Switzerand:Dept.of Medicine,Surgery and Neuroscience,University of Siena,Siena:and'IRCCS Istituto Neurologico Mediterraneo Neuromed,PozzilliItalyARTICLE IN FOABSTRACTArticle history:Background and Purpose:Target delineation in glioblastoma is still a matter of extensive research andReceived 3 March 2023debate.This guideline aims to update the existing joint European consensus on delineation of the clinicalReceived in revised form 23 March 2023target volume(CTV)in adult glioblastoma patients.Accepted 29 March 2023Available online 13 April 2023Material and Methods:The ESTRO Guidelines Committee identified 14 European experts in close interac-tion with the ESTRO clinical committee and EANO who discussed and analysed the body of evidence con-cerning contemporary glioblastoma target delineation,then took part in a two-step modified DelphiKeywords:Glioblastomaprocess to address open questions.Results:Several key issues were identified and are discussed including i)pre-treatment steps and immo-Target volumeDelineationbilisation,ii)target delineation and the use of standard and novel imaging techniques,and iii)technicalRadiotherapyaspects of
