Clinical Review EducationJAMA US Preventive Services Task Force RECOMMENDATION STATEMENTSerologic Screening for Genital Herpes InfectionUS Preventive Services Task ForceReaffirmation Recommendation StatementUS Preventive Services Task ForceEditorial page469IMPORTANCE Genital herpes is a common sexually transmitted infection caused by 2 relatedviruses,herpes simplex type1(HSV-1)and herpes simplex type 2(HSV-2).Infection is lifelong:⊕Multimediacurrently,there is no cure for HSVinfection.Antiviral medications may provide clinicalRelated article page510 andbenefits to symptomaticpersons.Transmission of HSV from a pregnant person to their infantJAMAPatientPage page 520can occur,most commonly during delivery;when genital lesions or prodromal symptoms areSupplemental contentpresent,cesarean delivery can reduce the risk of transmission.Neonatal herpes infection isRelatedarticle atuncommon yet can result insubstantial morbidity and mortality.jamademmatology.comOBJECTIVE To reaffirm its 2016 recommendation,the US Preventive Services Task Force(USPSTF)commissioned a reaffirmation evidence update on targeted key questionsto systematically evaluate the evidence on accuracy,benefits,and harms of routineserologic screening for HSV-2 infection in asymptomatic adolescents,adults,andpregnant persons.POPULATION Adolescents and adults,induding pregnant persons,without known history.signs,or symptoms of genital HSV infectionEVIDENCE ASSESSMENT The USPSTF concludes with moderate certainty that the harmsoutweighthe benefits for population-based screening for genital HSVinfection inAuthor/GroupInformation:The USasymptomatic adolescents and adults,includingpregnant persons.Preventive Services Task Force(USPSTF)members are listed at theRECOMMENDATION The USPSTF recommends against routine serologic screening forend of this artide.genital HSV infection in asymptomatic adolescents and adults,including pregnant persons.Corresponding Author:Carol M.(D recommendation)Mangione,MD,MSPH,David GeffenSchool of Medicine,University ofCalifomia,Los Angeles,109404MA.2023:329(6)502-507.doi:10.100jama.2023.0057Wilshire Blvd,Ste 700.Los Angeles.CA90024 (chair@uspstf.net).Summary of RecommendationPopulationRecommen由tionGradeAsymptomatic adolescentsThe USPSTF recommends against rout ine serologic screening for genitaland adults,includingher pes simplex virus infection in asymptomatic adolescents and adults,pregnant personsincluding pregnant persons.USPSTF indicates US PreventiveServices Task Force.See the Summary of Recommendation figure.fant can occur,most commonly during delivery:when genital le-Importancesions or prodromal symptoms are present,cesarean delivery canreduce the risk of transmission.34 Neonatal herpes infection is un-Genital herpes is a common sexually transmitted infection (STI)common yet can result in substantial morbidity and mortality.Cur-caused by 2 related viruses,herpes simplex type 1(HSV-1)and herpesrently,routine serologicscreening for genital herpes is limited by th
