La Revue de medecine interne 44(2023)62-71Disponible en ligne surElsevier Masson FranceScienceDirectEMconsultewww.sciencedirect.comwww.em-consulte.comELSEVIERReviewFrench practical guidelines for the diagnosis and management of AAamyloidosisRecommandations francaises de prise en charge de l'amylose AAS.Georgin-Lavialle,L.Savey,D.Buobd,J.-P.Bastard,S.Fellahi,A.Karras,J.-J.BoffaG.Grateau,collaborators!Sorbonne University.Internal medicine department,Tenon hospital Nationalreference center for autoinflamamtory diseases and AA amylodiosis(CEREMAIA),4 rue de la Chine,75020 Paris,FranceBiochemistry department.Henri-Mondor hospital Creteil FranceSorbonne University,Nephrology department,Tenon hospital Paris,FranceSorbonne University,department of pathology.Tenon hospital,Paris,Francee Paris centre university.Nephrology department,Georges Pompidou European hospital,Paris,FranceINFO ARTICLEABSTRACTHistorique de I'articleAA amyloidosis is secondary to the deposit of excess insoluble Serum Amyloid A(SAA)protein fibrils.AADisponible sur Intemet le 23 January 2023amyloidosis complicates chronic inflammatory diseases,especially chronic inflammatory rheumatismssuch as rheumatoid arthritis and spondyloarthritis:chronic infections such as tuberculosis,bronchec-tasia,chronic inflammatory bowel diseases such as Crohn's disease:and auto-inflammatory diseasesincluding familial Mediterranean fever.This work consists of the French guidelines for the diagnosisworkup and treatment of AA amyloidosis.We estimate in France between 500 and 700 cases in thewhole French population,affecting both men and women.The most frequent organ impaired is kidneywhich usually manifests by oedemas of the lower extremities,proteinuria,and/or renal failure.Patientsare usually tired and can display digestive features anf thyroid goiter.The diagnosis of AA amyloidosis isbased on detection of amyloid deposits on a biopsy using Congo Red staining with a characteristic greenAbbreviations:ACE,Angiotensine converting enzymeAlD.Auto-Inflammatory DiseaseAL,Light-chain amy loidosisANA,Antinuclear AntibodiesANCA,Anti-Neutrophil Cytoplasmic AntibodiesASCA.Anti-Saccharomyces Cerevisiae AntibodiesCAPS,Cryopyrin-associated periodic syndromeCBC,Complete blood countCeReMAIA,Referral Center for Auto-Inflammatory Diseases and Inflammatory AmyloidosisCKD-Epi,Chronic Kidney Disease-Epidemiology CollaborationCRP,C-reactive ProteinCVA,Cerebrovascular accident (stroke)FMF,Familial Mediterranean FeverGFR,Glomerular Filtration RateMDRD,Modification of Diet in Renal DiseaseRF,Rheumatoid FactorSAA,Serum Amyloid ATNF,Tumor Necrosis FactorTRAPS Tumor necrosis factor Receptor-Associated Periodic SyndromeTTR,TransthyretinTSH,Thyroid-stimulating hormoneVEGF,Vascular Endothelial Growth Factor.*Corresponding author.Adresse e-mail sophie.georgin-lavialle@aphp.fr(S.Georgin-Lavialle).Collaborators:Vincent AUDARD,nephrology,Creteil,France:Franck BRIDOUX,nephrology,Poitiers,France:Richard DAMADE,internal medicine,Chartres,France:S
