價Check for updatesReceived:27 December 2022 Accepted:27 December 2022D0L10.3322/caac21772ARTICLEColorectal cancer statistics,2023Rebecca L.Siegel MPH1 Nikita Sandeep Wagle MBBS,MHA,PhD1Andrea Cercek MD2 Robert A.Smith PhD3 Ahmedin Jemal DVM,PhD1Surveillance and Health Equity Science,T3224American Cancer Society,Atlanta,Georgia,AbstractUSAColorectal cancer (CRC)is the second most common cause of cancer death in the2Department of Medicine.Memorial SloanKettering Cancer Center,New York,NewUnited States.Every 3 years,the American Cancer Society provides an update ofYork.USACRC statistics based on incidence from population-based cancer registries and3Early Cancer Detection Science,Americanmortality from the National Center for Health Statistics.In 2023,approximatelyCancer Society.Atlanta,Georgia,USA153,020 individuals will be diagnosed with CRC and 52,550 will die from theCorrespondencedisease,including 19,550 cases and 3750 deaths in individuals younger thanon [1003/20231.Rebecca L Siegel,Surveillance Research,50 years.The decline in CRC incidence slowed from 3%-4%annually during theAmerican Cancer Society.3380 ChastainMeadows Par kway NW,Suite 200.Kennesaw.2000s to 1%annually during 2011-2019,driven partly by an increase inin-GA30144U5Adividuals younger than 55 years of 1%-2%annually since the mid-1990s.Email:rebecca.siegel@cancer.orgConsequently,the proportion of cases among those younger than 55 years2increased from 11%in 1995 to 20%in 2019.Incidence since circa 2010 increasedin those younger than 65 years for regional-stage disease by about 2%-3%annually and for distant-stage disease by 0.5%-3%annually,reversing the overallshift to earlier stage diagnosis that occurred during 1995 through 2005.Forexample,60%of all new cases were advanced in 2019 versus 52%in the mid-2000s and 57%in 1995,before widespread screening.There is also a shift toleft-sided tumors,with the proportion of rectal cancer increasing from 27%in1995 to 31%in 2019.CRC mortality declined by 2%annually from 2011-2020 overall but increased by 0.5%-3%annually in individuals younger than50 years and in Native Americans younger than 65 years.In summary,despitecontinued overall declines,CRC is rapidly shifting to diagnosis at a younger age,ata more advanced stage,and in the left colon/rectum.Progress against CRC couldbe accelerated by uncovering the etiology of rising incidence in generations bornsince 1950 and increasing access to high-quality screening and treatment amongall populations,especially Native Americans.KEYWORDScolon and rectum neoplasms,early-onset colorectal cancer,epidemiology,health disparitiesscreening and early detectionThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License,which permits use and distribution in anymedium,provided the original work is properly cited,the use is non-commercial and no modifications or adaptations are made.2023 The Authors.CA:A Cancer Journal for Clinicians published by Wiley Perio
