nature reviews rheumatologyhttps:/doi.org/10.1038/s41584-023-00958-wEvidence-based guidelinesCheck for updatesEvidence-Based Guideline forthe diagnosis and managementofeosinophilic granulomatosiswith polyangiitisAlist of authors and their affiliations appears at the end of the paperAbstractSectionsEosinophilic granulomatosis with polyangiitis(EGPA)is a rare anti-Introductionneutrophil cytoplasmic antibody (ANCA)-associated vasculitis,Methodscharacterized by asthma,eosinophilia and granulomatous or vasculiticRecommendationsinvolvement of several organs.The diagnosis and management of EGPAConclusionsare often challenging and require an integrated,multidisciplinaryapproach.Current practice relies on recommendations and guidelinesaddressing the management of ANCA-associated vasculitis and notspecifically developed for EGPA.Here,we present evidence-based,cross-discipline guidelines for the diagnosis and management of EGPAthat reflect the substantial advances that have been made in the pastfew years in understanding the pathogenesis,clinical subphenotypesand differential diagnosis of the disease,as well as the availability of newtreatment options.Developed by a panel of European experts on thebasis of literature reviews and,where appropriate,expert opinion,the 16 statements and five overarching principles cover the diagnosisand staging,treatment,outcome and follow-up of EGPA.Theserecommendations are primarily intended to beused by healthcareprofessionals,pharmaceutical industries and drug regulatoryauthorities,to guide clinical practice and decision-making in EGPA.These guidelines are not intended to limit access to medications byhealthcare agencies,nor to impose a fixed order on medication use.e-mail:augusto.vaglio@unifi.itNature Reviews Rheumatology
