Check for updatesREVIEWJBMRPLUS/ASBMRAsia-Pacific Consensus Recommendations on X-LinkedHypophosphatemia:Diagnosis,MultidisciplinaryManagement,and Transition From Pediatric toAdult CareCraig F Munns,12 Han-Wook Yoo,3 Muhammad Yazid Jalaludin,4 Rashida Vasanwala,5 Manju Chandran,5Yumie Rhee,Wai Man BUT,Alice Pik-Shan Kong,Pen-Hua Su,10.11 Nawaporn Numbenjapon,12Noriyuki Namba,3 Yasuo Imanishi,Roderick J Clifton-Bligh,15 Xiaoping Luo,6 and Weibo Xia7Child Health Research Centre,The University of Queensland,Brisbane,Australia2Department of Endocrinology and Diabetes,Queensland Children's Hospital,Brisbane,Australia3Department of Pediatrics,Bundang CHA Medical Center,CHA University School of Medicine,Seongnam-si KoreaDepartment of Pediatrics,Faculty of Medicine,Universiti Malaya,Kuala Lumpur,MalaysiaDepartment of Paediatric Medicine,Endocrine Diabetes Service,KK Women's Children's Hospital,Singapore,SingaporeOsteoporosis and Bone Metabolism Unit Department of Endocrinology,Singapore General Hospital,Singapore,SingaporeDepartment of Internal Medicine,Yonsei University College of Medicine,Seoul,KoreaDepartment of Pediatrics,Queen Elizabeth Hospital Hong KongDepartment of Medicine Therapeutics,The Chinese University of Hong Kong,Hong Kong1Department of Pediatrics,Chung Shan Medical University Hospital,Taichung,Taiwan1school of Medicine Chung Shan Medical University,Taichung,Taiwan12Division of Endocrinology,Department of Pediatrics,Phramongkutklao Hospital,Bangkok,Thailand1Department of Pediatrics and Perinatology,Faculty of Medicine,Tottori University,Tottori,JapanDepartment of Metabolism,Endocrinology and Molecular Medicine,Osaka Metropolitan University Graduate School of Medicine,Osaka,Japan5Department of Endocrinology,Royal North Shore Hospital,University of Sydney,Sydney,AustraliaDepartment of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China17Department of Endocrinology,Key Laboratory of Endocrinology,NHC,State Key Laboratory of ComplexSevere and Rare Diseases,Peking UnionMedical College Hospital,Chinese Academy of Medical Sciences Peking Union Medical College,Beijing.ChinaABSTRACTX-linked hypophosphatemia(XLH)is a rare,inherited,multisystem disorder characterized by hypophosphatemia that occurs second-ary to renal phosphate wasting.Mutations in PHEX gene (located at Xp22.1)in XLH alter bone mineral metabolism,resulting indiverse skeletal,dental,and other extraskeletal abnormalities that become evident in early childhood and persist into adolescenceand adult life.XLH impacts physical function,mobility,and quality of life,and is associated with substantial socioeconomic burdenand health care resource utilization.As the burden of illness varies with age,an appropriate transition of care from childhood andadolescence to adulthood is necessary to meet growth-related changes and minimize long-term sequelae of the condition.PreviousXLH guidelines that encompassed transition of care have focused on
