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THE END
Clinical and Translational Oncologyhttps:/doi.0g/10.1007/s12094-023-03177-7CLINICAL GUIDES IN ONCOLOGYSEOM-GEIS clinical guideline for gastrointestinal stromal tumors(2022)Cesar Serrano'.Rosa Alvarez2.Juan Antonio Carrasco3.Gloria Marquina.Jeronimo Martinez-Garcia5.Virginia Martinez-Marin5.Maria Angeles Sala?.Ana Sebio.Isabel Sevilla.Javier Martin-Broto10Received:23 March 2023/Accepted:24 March 2023©The Author(s)2O23AbstractGastrointestinal stromal tumor(GIST)is the most common malignant neoplasm of mesenchymal origin,and a paradigmaticmodel for a successful rational development of targeted therapies in cancer.The introduction of tyrosine kinase inhibitorswith activity against KIT/PDGFRA in both localized and advanced stages has remarkably improved the survival in a diseaseformerly deemed resistant to all systemic therapies.These guidelines are elaborated by the conjoint effort of the SpanishSociety of Medical Oncology (SEOM)and the Spanish Sarcoma Research Group(GEIS)and provide a multidisciplinaryand updated consensus for the diagnosis and treatment of GIST patients.We strongly encourage that the managing of thesepatients should be performed within multidisciplinary teams in reference centers.Keywords GIST.Imatinib.Ripretinib.AvapritinibCesar Serrano.Rosa Alvarez,Juan Antonio Carrasco,GloriaMarquina.Jeronimo Martinez-Garcfa.Virginia Martinez-Marin.Marfa Angeles Sala.Ana Sebio.Isabel Sevilla.and Javier Martin-Broto have contributed equally to the writing of the manuscript.Javier Martin-Broto☒Cesar Serranojmartin@atbsarc.orgcserrano@vhio.netRosa AlvarezSarcoma Translational Research Group,Vall d'Hebronrosa.alvarez.al@gmail.comInstitute of Oncology (VHIO),Hospital Universitario Valld'Hebron,Vall d'Hebron Barcelona Hospital Campus,C/Juan Antonio CarrascoNatzaret,115-117,08035 Barcelona,Spainjuan.antonio.carrasco.alvarez @sergas.es2 Hospital General Universitario Gregorio Maraiion,Madrid,Gloria MarquinaSpaingloriamarquina@hotmail.com3 Hospital Alvaro Cunqueiro-Complejo HospitalarioJeronimo Martinez-GarciaUniversitario de Vigo,Pontevedra,Spainjeronimo@seom.org4 Hospital Universitario Clinico San Carlos,Madrid,SpainVirginia Martinez-Marinvirgimarin9@hotmail.com5 Hospital Universitario Virgen de la Arrixaca.Murcia,SpainMaria Angeles Sala6Hospital Universitario la Paz,Madrid,Spainmariaangeles.salagonzalez@osakidetza.eus7 Hospital Universitario Basurto,Bilbao,SpainAna Sebio8 Hospital de la Santa Creu I Sant Pau,Barcelona,Spainasebio@santpau.cat9Hospitales Universitarios Regionaly Virgen de la Victoria,Isabel SevillaMalaga,Spainisevilla02@yahoo.es10 Hospital Universitario Fundacion Jimenez Diaz,Madrid,SpainPublished online:02 May 2023②Springer
