SEOM-GETNE胃肠胰和支气管神经内分泌肿瘤(NEN)诊断和治疗临床指南(2022)

Clinical and Translational Oncologyhttp5/doi.org/10.1007/s12094-023-03205-6CLINICAL GUIDES IN ONCOLOGYCpSEOM-GETNE clinical guidelines for the diagnosis and treatmentof gastroenteropancreatic and bronchial neuroendocrine neoplasms(NENs)(2022)Jaume Capdevila Castillon'.Teresa Alonso Gordoa2.Alberto Carmona Bayonas3.Ana Custodio Carretero4.Rocio Garcia-Carboneros.Enrique Grande Pulido5.Paula Jimenez Fonseca?.Angela Lamarca Lete8.Angel Segura HuertaJavier Gallego Plazas10Received:18 April 2023 Accepted:20 April 2023The Author(s)2023AbstractNeuroendocrine neoplasms (NENs)are a heterogeneous family of tumors of challenging diagnosis and clinical management.Their incidence and prevalence continue to rise mainly due to an improvement on diagnostic techniques and awareness.Earlier detection,along with steadfast improvements in therapy,has led to better prognosis over time for advanced gastroin-testinal and pancreatic neuroendocrine tumors.The aim of this guideline is to update evidence-based recommendations forthe diagnosis and treatment of gastroenteropancreatic and lung NENs.Diagnostic procedures,histological classification,and therapeutic options,including surgery,liver-directed therapy,peptide receptor radionuclide therapy,and systemic hor-monal,cytotoxic or targeted therapy,are reviewed and discussed,and treatment algorithms to guide therapeutic decisionsare provided.Keywords Guidelines·Neuroendocrine·Diagnosis·TherapyJaume Capdevila CastillonServicio de Oncologia Medica,Hospital Universitario Valljacapdevila@vhebron.netD'Hebron,Ps Vall d'Hebron,119-129,08035 Barcelona,Teresa Alonso GordoaSpaintalonsogordoa@gmail.comServicio de Oncologia Medica.Hospital UniversitarioAlberto Carmona BayonasRamon y Cajal,Madrid,Spainalberto.car monabayonas@gmail.com3Servicio de Oncologfa Medica.Hospital UniversitarioAna Custodio CarreteroMorales Meseguer,Murcia,Spainanabcustodio@gmail.com4Servicio de Oncologia Medica,Hospital Universitario LaRocio Garcia-CarboneroPaz,Madrid,Spainrgcarbonero@gmail.comServicio de Oncologia Medica,Hospital Universitario 12 deEnrique Grande PulidoOctubre,Madrid,Spainegrande@mdanderson.esServicio de Oncologia Medica,MD Anderson Cancer Center.Paula Jimenez FonsecaMadrid,Spainpalucaji@hotmail.comServicio de Oncologia Medica,Hospital UniversitarioAngela Lamarca LeteCentral de Asturias,Oviedo,Spainangela.lamarca@quironsalud.esServicio de Oncologia Medica,Hospital UniversitarioAngel Segura HuertaFundacion Jimenez Diaz,Madrid,Spainsegura_ang@gva.esServicio de Oncologia Medica,Hospital Universitari IJavier Gallego PlazasPolitecnic la Fe,Valencia,Spainj.gallegoplazas@gmail.com10Servicio de Oncologfa Medica.Hospital GeneralUniversitario de Elche.Alicante,SpainPublished online:19 May 2023Springer