真Check for updatesReceived:11 January 2023Revised:11 February 2023Accepted:18 February 2023D0t10.1111/hepr.13892GUIDELINESClinical Practice Guidelines for Hepatocellular Carcinoma:The Japan Society of Hepatology 2021 version(5th JSH-HCC Guidelines)Kiyoshi Hasegawa1 Nobuyuki Takemura2 Tatsuya Yamashita3Takeyuki Watadani Masaki Kaibori5 Shoji Kubo5 Mitsuo Shimada7Hiroaki Nagano Etsuro Hatano Hiroshi Aikata10 Hiroko lijima11Kazuomi Ueshima12 Kazuyoshi Ohkawa13 Takuya Genda14Kaoru Tsuchiya15 Takuji Torimura16 Masafumi lkeda17 Junji Furuse18Masaaki Akahane19 Satoshi Kobayashi20 Hideyuki Sakurai21Atsuya Takeda22 Takamichi Murakami23 Utaroh Motosugi24Yutaka Matsuyama25 Masatoshi Kudo12 Ryosuke Tateishi26The committee for Revision of the Clinical Practice Guidelines for Hepatocellular Carcinoma,Tokyo,JapanCorrespondenceKiyoshi Hasegawa,Hepato-Biliary-PancreaticAbstractSurgery Division,Artificial Organ andThe fifth version of the Clinical Practice Guidelines for Hepatocellular CarcinomaTransplantation Surgery Division,Departmentof Surgery.Graduate School of Medicine,Thewas revised by the Japan Society of Hepatology,according to the methodology ofUniversity of Tokyo,7-3-1 Hongo,Bunkyo-ku.evidence-based medicine and partly to the Grading of Recommendations Assess-Tokyo 113-8655.Japan.Email:hasegawa-2su@h.u-tokyo.ac.jpment,Development and Evaluation system,which was published in October 2021 inJapanese.In addition to surveillance-diagnostic and treatment algorithms,a newFunding informationNone.algorithm for systemic therapy has been created,as multiple drugs for hepatocel-lular carcinoma can be currently selected.Here,new or revised algorithms andevidence on which the recommendations are based are described.KEYWORDSalgorithm for surveillance and diagnosis,algorithm for systemic therapy,algorithm fortreatment,clinical practice guidelines,hepatocellular carcinomaINTRODUCTIONfourth version of Evidence-based Clinical Practice Guidelines for HCCwas published in 2017,5 followed by Web-based minor revisions to theSince the first edition of the Clinical Practice Guidelines for Hepato-evidence for new systemic therapies,and the expanded fourth editioncellular Carcinoma(HCC)was published in 2005,revisions have beenwith the modification of the treatment algorithm for the indication ofmade by the Japan Society of Hepatology(JSH)every 4years.2-4 Theliver transplantation for HCC in 2020.The revision of the 2021 versionThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License,which permits use and distribution in anymedium,provided the original work is properly cited,the use is non-commercial and no modifications or adaptations are made.2023 The Authors.Hepatology Research published by John Wiley Sons Australia,Ltd on behalf of Japan Society of Hepatology.Hepatology Research 2023:1-8.wileyonline library.com/journal/hepr1
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