HistopathologyHistopathology 2023 DOI:10.1111/his.14902Consensus based recommendations for the diagnosis ofserous tubal intraepithelial carcinoma:an internationalDelphi studyJoep M A Bogaerts,Majke H D van Bommel,2 Rosella P M G Hermens,3Miranda P Steenbeek,2 Joanne A de Hullu,2 Jeroen A W M van der Laak,1.4 STIC consortiumMichiel Simons'Department of Pathology.2Department of Obstetrics and Gynecology,3IQ Healthcare,Radboud Institute of Health/10./his.Sciences,Radboud University Medical Center,Nijmegen,the Netherlands andCenter for Medical Image Science andVisualization,Linkoping University,Linkoping,SwedenDate of submission 21 December 2022Accepted for publication 25 February 2023Published online Article Accepted xx-xx-xxBogaerts J M A,van Bommel M H D.Hermens R P M G.Steenbeek M P.de Hullu J A,van der Laak J A W M.on [21032023].STIC consortium Simons M(2023)Histopathology.https://doi.org/10.1111/his.14902Consensus based recommendations for the diagnosis of serous tubal intraepithelial carci-noma:an international Delphi studyAim:Reliably diagnosing or safely excluding serousmembers.Finally,each expert was asked to approvetubal intraepithelial carcinoma (STIC).a precursoror disapprove the complete set of consensus state-lesion of tubo-ovarian high-grade serous carcinomaments.The panel indicated their level of agreement(HGSC).is crucial for individual patient care.for bet-with 64 statements.A total of 27 statements (42%)ter understanding the oncogenesis of HGSC,and forreached consensus after three rounds.These state-safely investigating novel strategies to prevent tubo-ments reflect the entire diagnostic work-up for pathol-ovarian carcinoma.To optimize STIC diagnosis andogists.regarding processing and macroscopy (threeincrease its reproducibility.we set up a three-roundstatements):microscopy (eight statements):immuno-Delphi study.histochemistry (nine statements):interpretation andMethods and results:In round 1.an internationalreporting (four statements):and miscellaneous (threeexpert panel of 34 gynecologic pathologists.from 11statements).The final set of consensus statements wascountries.was assembled to provide input regardingapproved by 85%.STIC diagnosis.which was used to develop a set ofConclusion:This study provides an overview of cur-statements.In round 2,the panel rated their level ofrent clinical practice regarding STIC diagnosisagreement with those statements on a 9-point Likertamongst expert gynecopathologists.The experts'con-scale.In round 3.statements without previous con-sensus statements form the basis for a set of recom-sensus were rated again by the panel while anony-mendations.which may help towards moremously disclosing the responses of the other panelconsistent STIC diagnosis.Keywords:Delphi study,diagnostic consensus criteria,high-grade serous carcinoma(HGSC),serous tubalintraepithelial carcinoma (STIC)Address for correspondence:J M A Bogaerts.Radboudumc.Department of Pathology.824.Postbus 9101.6500 HB Nijmegenthe Netherlands.
