2022JPS临床实践指南：胰腺癌（概要）

International Journal of Clinical Oncologyhttp5/doi.org/10.1007/s10147-023-02317-xSPECIAL ARTICLEClinical Practice Guidelines for Pancreatic Cancer 2022 from the JapanPancreas Society:a synopsisTakuji Okusaka.Masafumi Nakamura2.Masahiro Yoshida3.Masayuki Kitano4.Yoshinori Ito5.Nobumasa Mizuno5.Keiji Hanada?.Masato Ozaka.Chigusa Morizane'.Yoshifumi Takeyamaon behalf of theCommittee for Revision of Clinical Guidelines for Pancreatic Cancer of the Japan Pancreas SocietyReceived:19 October 2022/Accepted:14 February 2023©The Author(s)2023AbstractObjectives Clinical Practice Guidelines for Pancreatic Cancer was first published in 2006 by the Japan Pancreas Society,and revised in 2009,2013,2016,and 2019.In July 2022,Clinical Practice Guidelines for Pancreatic Cancer was newlyrevised in Japanese.Methods For this revision,we developed an entirely new guideline according to the Minds Manual for Guideline Develop-ment 2020,which includes the concepts of GRADE-Grading Recommendations Assessment,Development,and Evalu-ation,to enable a better understanding of the current guidelines.Patients and the public were actively involved in both thedevelopment and implementation of the guideline.Results The guideline includes algorithms for diagnosis,treatment,chemotherapy,and precision medicine of pancreaticcancer,and addresses 7 subjects:diagnosis,surgical therapy,adjuvant therapy,radiation therapy,chemotherapy,stent therapy,and supportive palliative medical care.It includes 73 clinical questions and 112 statements.The statements correspondto the clinical questions,evidence levels,recommendation strengths,and agreement rates.Conclusions This guideline represents the most standard clinical and practical management guideline available until datein Japan.This is the English synopsis of the Clinical Practice Guidelines for Pancreatic Cancer 2022 in Japanese,and is anattempt to disseminate the Japanese guideline worldwide to introduce the Japanese approach to the clinical management ofpancreatic cancer.Keywords Pancreatic cancer.Clinical guidelines.Japan Pancreas Society.Minds.GRADE systemAbbreviationsEUSEndoscopic ultrasonographyBRBorderline resectableEUS-FNAEndoscopic ultrasonography-fine-needleCTComputed tomographyaspirationERCPEndoscopic retrogradeJPSJapan Pancreas Societycholangiopancreatography☒Takuji Okusaka5Department of Radiation Oncology,Showa Universitytokusaka@ncc.go.jpSchool of Medicine,Tokyo,Japan6Department of Hepatobiliary and Pancreatic Oncology,Department of Gastroenterology.Aichi Cancer CenterNational Cancer Center Hospital,5-1-1 Tsukiji,Chuo-ku,Hospital,Nagoya,JapanTokyo 104-0045,Japan7Department of Gastroenterology.JA Onomichi GeneralHospital,Onomichi,JapanDepartment of Surgery and Oncology.Graduate Schoolof Medical Sciences,Kyushu University.Fukuoka,JapanHepato-Biliary-Pancreatic Medicine Department,Cancer3Department of Hepato-Biliary-Pancreatic and GI Surgery,Institute Hospital,Tokyo,JapanInternational University of Health and Welfare,Ichikawa,Depart