Consensus GuidelinesNeonatologyNeonatology 2023;120:3-23Received:November 7,2022D0l10.1159/000528914Accepted:December 12,2022Published online:February 15,2023European Consensus Guidelines on theManagement of Respiratory DistressSyndrome:2022 UpdateDavid G.Sweeta Virgilio P.Carniellib Gorm Greisen Mikko HallmandKatrin Klebermass-Schrehofe Eren Ozekf Arjan te Pas9 Richard PlavkahCharles C.Roehri Ola D.Saugstadi.k Umberto Simeoni!Christian P.SpeermMaximo Venton Gerry H.A.Vissero Henry L.HallidayPRegional Neonatal Unit,Royal Maternity Hospital,Belfast,UK;bDepartment of Neonatology,University PolytechnicDella Marche,University Hospital Ancona,Ancona,Italy;Department of Neonatology,Rigshospitalet and Universityof Copenhagen,Copenhagen,Denmark;Department of Children and Adolescents,Oulu University Hospital andMedical Research Center,University of Oulu,Oulu,Finland;Department of Pediatrics and Adolescent Medicine,Division of Neonatology,Medical University of Vienna,Vienna,Austria;'Department of Pediatrics,Mar maraUniversity Medical Faculty,Istanbul,Turkey;9Leiden University Medical Centre,Leiden,The Netherlands;hDivision of Neonatology,Department of Obstetrics and Gynecology,General Faculty Hospital and 1st Facultyof Medicine,Charles University,Prague,Czech Republic 'Faculty of Health Sciences,University of Bristol,UK andNational Perinatal Epidemiology Unit,Oxford Population Health,Medical Sciences Division,University of Oxford,Oxford,UK:iDepartment of Pediatric Research,Oslo University Hospital Rikshospitalet,University of Oslo,Oslo,Norway;Ann and Robert H.Lurie Children's Hospital of Chicago,Northwestern University Feinberg School ofMedicine,Chicago,IL,USA:University of Lausanne,Lausanne,Switzerland;mDepartment of Pediatrics,UniversityChildren's Hospital,Wuerzburg,Germany;"Department of Pediatrics and Neonatal Research Unit,HealthResearch Institute La Fe,University and Polytechnic Hospital La Fe,Valencia,Spain;Department of Obstetrics andGynecology,University Medical Centre,Utrecht,The Netherlands;PDepartment of Child Health,Queen's UniversityBelfast and Royal Maternity Hospital,Belfast,UKKeywordspanel of experienced European neonatologists and an ex-Antenatal corticosteroids.Continuous positive airwaypert perinatal obstetrician based on available literature up topressure.Evidence-based practice.Mechanical ventilation.end of 2022.Optimising outcome for babies with RDS in-Non-invasive respiratory support.Nutrition.Oxygencludes prediction of risk of preterm delivery,appropriatesupplementation.Patent ductus arteriosus.Pretermmatemal transfer to a perinatal centre,and appropriate andinfant.Respiratory distress syndrome.Surfactant therapy.timely use of antenatal steroids.Evidence-based lung-pro-Thermoregulationtective management includes initiation of non-invasive re-spiratory support from birth,judicious use of oxygen,earlysurfactant administration,caffeine therapy,and avoidanceAbstractof intubation and mechanical ventilation where possible.Respiratory dis