nature reviews nephrologyhttps:/doi.org/10.1038/s41581-023-00683-3Consensus statementCheck for updatesSepsis-associated acute kidneyinjury:consensus report ofthe 28th Acute Disease QualityInitiative workgroupAlist of authors and their affiliations appears at the end of the paperAbstractSectionsSepsis-associated acute kidney injury(SA-AKI)is common in criticallyIntroductionill patients and is strongly associated with adverse outcomes,includingMethodsanincreased risk of chronic kidney disease,cardiovascular eventsDefinition and epidemiologyand death.The pathophysiology ofSA-AKI remains elusive,althoughof SA-AKImicrocirculatory dysfunction,cellular metabolic reprogrammingPathophysiology of SA-AKIand dysregulated inflammatory responses have been implicated inand novel mechanismspreclinical studies.SA-AKI is best defined as the occurrence of AKIFluid and resuscitation therapywithin 7 days of sepsis onset(diagnosed according to Kidney DiseaseBiomarkers for diagnosisImproving Global Outcome criteria and Sepsis 3 criteria,respectively).and guiding treatmentImproving outcomes in SA-AKI is challenging,as patients can presentExtracorporeal therapieswith either clinical or subclinical AKI.Early identification of patientsfor SA-AKIat risk of AKI,or at risk of progressingto severe and/or persistent AKI,SA-AKI:the paediatricis crucial to the timely initiation of adequate supportive measures,perspectiveincluding limiting further insults to the kidney.Accordingly,theConclusionsdiscovery of biomarkers associated with AKI that can aid in earlydiagnosis is an area of intensive investigation.Additionally,high-qualityevidence onbest-practice care of patients with AKI,sepsis and SA-AKIhas continued to accrue.Although specific therapeutic options arelimited,several clinicaltrials have evaluated the use ofcare bundlesand extracorporeal techniques as potential therapeutic approaches.Here we providegraded recommendations for managing SA-AKI andhighlight priorities for future research.e-mail:luiforni@nhs.netNature Reviews Nephrology
