角Check for updatesReceived:19 September 2022 Accepted:9 November 2022https://doi.org/10.1016/j.jtha.202211014jthISTH SSC COMMUNICATIONAnticoagulation in adult patients supported withextracorporeal membrane oxygenation:guidance from theScientific and Standardization Committees on Perioperativeand Critical Care Haemostasis and Thrombosis of theInternational Society on Thrombosis and HaemostasisJulie Helms1 Corinne Frere2 Thomas Thiele3 Kenichi A.TanakaMatthew D.Neal5 Marie E.Steiner5 Jean M.Connors?Jerrold H.Levy3iStrasbourg University(UNISTRA)Strasbourg University Hospital.MedicalAbstractIntensive Care Unit-NHC,INSERM (FrenchNational Institute of Health and MedicalAnticoagulation of patients supported by extracorporeal membrane oxygenation isResearch).UMR 1260,Regenerativechallenging because of a high risk of both bleeding and thrombotic complications,andNanomedicine (RNM).FMTS,Strasbourg.often empirical.Practice in anticoagulation management is therefore highly variable.France2Sorbonne Universite,UMRS 1166 AP-HP.The scope of this guidance document is to provide clinicians with practical advice onSorbonne Universite,Pitie-Salpetrierethe choice of an anticoagulant agent,dosing,and the optimal anticoagulant monitoringHospital,Paris,Francestrategy during extracorporeal membrane oxygenation support in adult patients.nstitut fur Transfusionsmedizin.Universifatsmedizin Rostock,Schillingallee36,Rostock,GermanyKEYWORDSanticoagulation,extracorporeal membrane oxygenation,critical careDepartment of Anesthesiology.Universit ofOklahoma Health Sciences Center,Oklahoma City.OK,USA5Department of Surgery.Trauma andTransfusion Medicine Research Center,University of Pittsburgh,Pittsburgh,PA.USADivision of Hematology/Oncology andDivision of Critical Care,Department ofPediatrics,University of Minnesota,Minneapolis,MN,USA7Hematology Division.Brigham andWomen's Hospital,Harvard Medical SchoolBoston.MA.USADepartment of Anesthesiology.CriticalCare,and Surgery.Duke University Schoolof Medicine,Durham,NC,USAManuscript handled by:Walter AgenoFinal decision:Walter Ageno.09 November 20222022 International Society on Thrombosis and Haemostasis.Published by Elsevier Inc.All rights reserved.JThromb Hemost.2023:21:373-396jthisthorg373
