肿瘤药学2023年2月第13卷第1期Anti-tumor Pharmacy,February 2023,Vol.13,No.I规范·指南·共识▣▣D0I:10.3969/i.ism.2095-1264.2023.01.01文章编号：2095-1264(2023)01-0001-10妇科恶性肿瘤放化疗期间应用聚乙二醇化重组人粒细胞集落刺激因子(PEG-rhG-CSF)的中国专家共识(2023年版)中国医院协会妇产医院分会妇科肿瘤专业学组，中国医师协会微无创医学专业委员会妇科肿霜学组摘要：中性粒细胞减少症是妇科恶性肿璃放化疗最常见的血液学毒性，可导致后续治疗延迟和剂量减少，并易引发中性粒细胞减少性发热及严重感柒，影响患者预后。重视中性粒细胞减少症的危害，对其进行风险评估和规范性防治具有重要意义。聚乙二醇化重组人粒细胞集落制激因子(PEG-hG-CSF)作为重组人粒细胞集落制激因子（山G-CSF)的长效制剂，可预防和治疗中性粒细胞减少症，临床使用便捷。为促进临床合理用药，本共识制定小组以循证证据为基础，评估其在妇科恶性肿痛放化疗期间应用的有效性及安全性，明确预防与治疗的临床路径及给药方式，形成妇科恶性肿瘠放化疗期间应用PEG-hG-CSF的中国专家共识。关键词：妇科恶性肿瘡；放化疗；中性粒胞减少症；聚乙二醇化重组人粒细胞集落刺激因子中图分类号：R737.3文献标识码：AChinese expert consensus on the application of pegylated recombinanthuman granulocyte colony-stimulating factor (PEG-rhG-CSF)duringchemoradiotherapy for gynecological malignancies (2023 Edition)Gynecologic Oncology Group of Obstetrics and Gynecology Hospital Branch of Chinese Hospital Association,Gynecologic Oneology Group of Minimally Invasive and Noninvasive Medicine Committee of Chinese Medical Doctor AssociationAbstract:Neutropenia is the most common hematologic toxicity of chemoradiotherapy for gynecological malignancies.It can lead to the delay and dose reduction of follow-up treatment,induce febrile neutropenia and severe infection easily,and affect the prognosis of patients.It is of great significance to pay attention to the harm of neutropenia and to carry outrisk assessment and standardized prevention and treatment.The pegylated recombinant human granulocyte colony-stimulat-ing factor(PEG-rhG-CSF),as a long-acting preparation of recombinant human granulocyte colony-stimulating factor(rhG-CSF),can prevent and treat neutropenia and is convenient for clinical use.In order to promote clinical rational administra-tion of drugs,based on evidence-based evidence,the consensus formulation team evaluated the efficacy and safety of its ap-plication during chemoradiotherapy for gynecological malignancies,defined the clinical pathway and administration modeof prevention and treatment,and then formed the Chinese expert consensus on the application of PEG-rhG-CSF duringchemoradiotherapy for gynecological malignancies.Keywords:Gynecological malignancies;Chemoradiotherapy:Neutropenia;PEG-rhG-CSF放化疗是妇科恶性肿瘤的重要治疗手段，其最迟和剂量减少，进而降低临床疗效。粒细胞集落刺常见的血液学毒性为骨髓抑制，尤其是中性粒细胞激因子(granulocyte colony-stimulating factor,减少症(neutropenia),严重者可引起中性粒细胞减G-CSF)是预防和治疗中性粒细胞减少症的主要药少性发热(febrile neutropenia,FN),甚至继发严重感物，常用药物包括重组人粒细胞集落刺激因子(e染、中毒性休克，乃至危及生命，导致后续治疗延combinant human granulocyte colony-stimulating fac--1-(C)1994-2023 China Academic Journal Electronic Publishing House.All rights reserved.http://www.cnki.net
