Journal of Pain ResearchDovepressopen access to scientific and medical researchREVIEWEvidence-Based Clinical Guidelines from theAmerican Society of Pain and Neuroscience forthe Use of Implantable Peripheral NerveStimulation in the Treatment of Chronic PainNatalie Strand,Ryan S D'Souza2,Jonathan M Hagedorn3,Scott Pritzlaff,Dawood Sayed5Nomen Azeem5,Alaa Abd-Elsayed,Alexander Escobar8,Mark A Huntoon,Christopher M Lam5,Timothy R Deer0Department of Anesthesiology.Division of Pain Medicine,Mayo Clinic,Scottsdale,AZ USA;2Department of Anesthesiology and PerioperativeMedicine,Division of Pain Medicine,Mayo Clinic,Rochester,MN,USA;3iSpine Pain Physicians,Burnsville,MN,USA;Department of Anesthesiologyand Pain Medicine,Division of Pain Medicine.University of California-Davis,Sacramento,CA.USA:SThe University of Kansas Medical Center,KansasCity.KS.USA;Florida Spine Pain Specialists,Bradenton FL USA;Department of Anesthesiology.University of Wisconsin,Madison,WI,USA;Comprehensive Centers for Pain Management Toledo.OH.USA;Department of Anesthesiology.Virginia Commonwealth University.Henrico,VAUSA;The Spine and Nerve Center of the Virginias,Charleston,WV.USACorrespondence:Natalie Strand,Department of Anesthesiology.Division of Pain Medicine Mayo Clinic,Scottsdale,AZ USA Tel+480-301-8000.Fax+I 480-342-2986,Email strand.natalie@mayo.eduAbstract:The objective of this peripheral nerve stimulation consensus guideline is to add to the current family of consensus practiceguidelines and incorporate a systematic review process.The published literature was searched from relevant electronic databases,including PubMed,Scopus,Cochrane Central Register of Controlled Trials,and Web of Science from database inception to March 29,2021.Inclusion criteria encompassed studies that described peripheral nerve stimulation in patients in terms of clinical outcomes forvarious pain conditions,physiological mechanism of action,surgical technique,technique of placement,and adverse events.Twentyrandomized controlled trials and 33 prospective observational studies were included in the systematic review process.There is LevelI evidence supporting the efficacy of PNS for treatment of chronic migraine headaches via occipital nerve stimulation,chronichemiplegic shoulder pain via stimulation of nerves innervating the trapezius,supraspinatus,and deltoid muscles;failed back surgerysyndrome via subcutaneous peripheral field stimulation;and lower extremity neuropathic and lower extremity post-amputation pain.Evidence from current Level I studies combined with newer technologies facilitating less invasive and easier electrode placementmake peripheral nerve stimulation an attractive alterative for managing patients with complex pain disorders.Peripheral nervestimulation should be used judiciously as an adjunct for chronic and acute postoperative pain following adequate patient screening andpositive diagnostic nerve block or stimulation trial.Keywords:post-amputation pain,low back pain,peripheral neur